Publications by authors named "Bui Phuong Thao"

Article Synopsis
  • - Landslides threaten lives and infrastructure in mountainous areas, and monitoring them in real-time can be challenging and costly due to harsh conditions.
  • - This study developed deep learning models to automatically detect landslide traces using Sentinel-2 satellite images, focusing on three U-shaped architectures: U-Net, U2-Net, and U-Net3+.
  • - The U-Net model with a 32 × 32 input size achieved a high detection accuracy of 97%, allowing for better monitoring of landslide risks and providing timely warnings to local communities about potential flash floods during wet seasons.
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Article Synopsis
  • * A study involving 70 infants diagnosed with NDM at the Vietnam National Children's Hospital found that 78.5% had known mutations, with many experiencing diabetic complications but showing normal development after 5.5 years of insulin treatment.
  • * The research highlights that certain mutations are a common cause of permanent NDM and suggests that genetic screening for these mutations should be part of the diagnosis process for diabetic children in their first year of life.
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Background: Neonatal diabetes mellitus (NDM) is defined as insulin-requiring persistent hyperglycemia occurring within the first 6 months of life, which can result from mutations in at least 25 different genes. Activating heterozygous mutations in genes encoding either of the subunits of the ATP-sensitive K channel (K channel; or ) of the pancreatic beta cell are the most common cause of permanent NDM and the second most common cause of transient NDM. Patients with NDM caused by K channel mutations are sensitive to sulfonylurea (SU) treatment; therefore, their clinical management can be improved by replacing insulin with oral agents.

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Most patients with spinal muscular atrophy (SMA) have been reported to show homozygous deletion of the gene responsible for SMA, SMN1. However, whether SMA patients homozygous for the SMN1 deletion exist in Southeast Asian countries, including Vietnam, remains to be determined, because molecular genetic analyses of SMA patients from these countries have not been reported. In this preliminary study, we analyzed five Vietnamese SMA patients and found that SMN1 gene exons 7 and 8 were completely absent in one of them, a 6-month-old girl with hypotonic muscles.

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