Publications by authors named "Bui Hai Ha"
Ultra-Deep Massive Parallel Sequencing of Plasma Cell-Free DNA Enables Large-Scale Profiling of Driver Mutations in Vietnamese Patients With Advanced Non-Small Cell Lung Cancer.
Le Son Tran Quynh-Tho Thi Nguyen Chu Van Nguyen Vu-Uyen Tran Thai-Hoa Thi Nguyen Ha Thu Le Lam-Son Pham Binh Thanh Vo Luan Thanh Nguyen Hong-Anh Thi Pham Thanh-Truong Tran Thanh-Thanh Thi Nguyen Hai-Ha Bui Thanh-Thuy Thi Do Minh-Duy Phan
Front Oncol
August 2020
Article Synopsis
- Population-specific profiling of cancer gene mutations is essential for better understanding cancer biology and improving diagnostics and treatment tailored to specific groups.
- The study used ultra-deep massive parallel sequencing of plasma cell-free DNA (cfDNA) to analyze mutations in 265 Vietnamese patients with advanced non-small cell lung cancer, offering a less invasive alternative to traditional tumor tissue analysis.
- Although cfDNA testing had lower mutation detection rates, it still identified major mutations in key driver genes that were consistent with findings from tissue sample analysis, highlighting its potential for large-scale genetic profiling in populations with limited access to tumor biopsies.
Hereditary breast cancer is an inherited genetic condition, mainly caused by and gene mutations. These genetic changes can increase the risks of breast and ovarian cancers in women, while prostate and breast cancers in men. Especially, mutations in either or genes take important roles in early-onset breast cancer.
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