Publications by authors named "Buesra Zengin"

Objective: To determine the effects of sunflower seed oil and coconut oil on the skin integrity and weight gain of preterm infants in the neonatal ICU.

Methods: In this randomized controlled trial, 66 preterm neonates (34-37 weeks' gestation) in the neonatal ICU of a training and research hospital were equally divided into three groups: sunflower seed oil, coconut oil, and control. The weights of neonates in all three groups were measured at admission to the neonatal ICU, at discharge, and at 1 month postdischarge.

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IKZF1 deletions (ΔIKZF1) are common in precursor B-cell acute lymphoblastic leukemia (B-ALL) and are assumed to have a prognostic impact. We aimed to determine the prognostic implications of ΔIKZF1 and CRLF2 overexpression in pediatric B-ALL. Furthermore, we sought to compare the multiplex polymerase chain reaction (PCR) assay with standard multiplex ligand-dependent probe amplification (MLPA) methods to ascertain IKZF1 status in a clinical context.

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Article Synopsis
  • The study investigated the role of inflammation-related biomarkers (SII, SIRI, NLR, PLR) in predicting mid-term mortality and restenosis in patients with peripheral artery disease (PAD).
  • During an average follow-up of about 21 months, researchers found that higher levels of these biomarkers correlated with increased mortality rates, particularly highlighting NLR as a significant independent risk factor.
  • However, no significant links were established between these biomarkers and the occurrence of restenosis in the study participants.
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The current work represents a comparative study of the phenolic profiles of three under-explored (Boraginaceae) species from Greece- (OL), (OE), and (OG). Although spp. have ethnopharmacological significance, previous phytochemical studies have focused primarily on roots.

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This study provides the first comprehensive evaluation of the bioactive potential of acorn flour extracts (, Fagaceae) prepared at different temperatures (20, 60, 80 and 100 °C), focusing on polyphenolic content, antioxidant properties and enzyme inhibitory activities. Through HPLC-ESI-MS/MS analysis, 36 bioactive compounds were identified, with the extract at 60 °C showing the highest concentrations of key polyphenols, notably gallic acid (210,008.9 mg·kg) and ellagic acid (45,469.

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Oxadiazole compounds are of great interest because they have a range of biological activities ranging from antioxidants to anticancer agents. Against this background, we wanted to demonstrate the antioxidant, enzyme inhibitory, and anticancer effects of 5(4-hydroxyphenyl)-2-(N-phenylamino)-1,3,4-oxadiazole (Hppo). Antioxidant abilities were measured through free radical scavenging and reducing power tests.

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The Anatolian honey bee (Apis mellifera anatoliaca) and Bombus terrestris are important species in Türkiye. In this context, protecting the health of these honey bees is particularly important. Lactic acid bacteria (LAB) and acetic acid bacteria (AAB) are very important for the health of bees.

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Background: We aimed to contribute to the literature by exploring the possible relationship of PV with erectile dysfunction (ED), as in atherosclerosis-based vascular diseases.

Methods: Between October 2021 and December 2022, 99 patients who applied to the urology polyclinic with a complaint of ED were included in the study (Group 1). Fifty-two patients who applied with a complaint other than ED constituted the control group (Group 2).

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Background: Parkinson's disease (PD) is the fastest-growing neurological disorder globally. Defining features include tremor, muscular rigidity, bradykinesia, and postural instability, which in combination with nonmotor symptoms such as cognitive impairment and orthostatic hypotension increase the risk of falls. Along with low bone mineral density, fracture risk is high in PD.

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Background: Earthquakes cause significant psychological and physical trauma in children, especially when leading to amputations, as they disrupt physical, emotional, and social well-being.

Aim: This study was conducted phenomenologically to explore the experiences of children amputated in the Kahramanmaraş earthquake and their parents/caregivers.

Method: This study was conducted as a phenomenological study with children who were amputated in the Kahramanmaraş earthquake and their parents/caregivers between August and October 2023.

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Background: Intracranial hemorrhage (ICH) is reportedly rare but has high morbidity and mortality risk in persons with hemophilia. Although the risk factors that facilitate bleeding are known, the factors affecting the sequelae are not well known.

Objectives: We planned to investigate the risk factors for neurologic sequelae in children and adolescents with hemophilia suffering from ICH.

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The present study investigates the chemical profile and biological activities of M. Keskin, a species endemic to Turkey, aiming to explore its potential applications in pharmacology. We assessed its phenolic and flavonoid content by employing ethyl acetate, methanol, and water as extraction solvents.

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Dual-targeting drug design has become a popular approach in investigating and developing potent anticancer agents. In this regard, carbonic anhydrase (CAIX) and vascular endothelial growth factor receptor (VEGFR-2) are emerging as highly effective targets in the battle against cancer. In the present study, two series of 4-thiazolidinones/2,4-thiazolidinediones carrying 2-methylbenzenesulfonamide derivatives were designed and synthesized as potential dual CAIX/VEGFR-2 inhibitors.

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Background: Non-laboratory-based cardiovascular risk prediction tools are feasible alternatives to laboratory-based tools in low- and middle-income countries. However, their effectiveness compared to their laboratory-based counterparts has not been adequately tested.

Aim: We compared estimates from laboratory-based and non-laboratory-based risk prediction tools in a low- and middle-income country setting.

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BACKGROUND Shiga toxin-producing Escherichia coli (STEC) causes serious bacterial illnesses from consuming undercooked meat and foods contaminated with feces. This study aimed to describe the characteristics of an STEC outbreak associated with hemolytic uremic syndrome (HUS) that emerged in Turkey and affected 21 adults. MATERIAL AND METHODS The medical records of 21 adult patients who were admitted to Ankara Bilkent City Hospital Internal Medicine Intensive Care Department with the diagnosis of HUS between July and September 2022 were retrospectively evaluated through the system.

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The genus Thesium, family Santalaceae, comprises about 350 species, and, although many of them are used as functional food and in traditional medicine, there are limited studies evaluating their pharmacological potential. The present study was designed to evaluate the chemical profile, antioxidant, and enzyme inhibition potential of aerial parts and roots of T. bertramii Azn.

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The Verbascum genus has gained significant attention in the pharmaceutical field, particularly in recent years, due to its valuable medicinal properties, which are well-recognized in complementary and alternative medicine. Certain species within this genus contain essential compounds and exhibit a wide range of therapeutic activities. In this study, the ethanolic extract of Verbascum gimgimense (VG) was analyzed for its cytotoxic, apoptotic, antioxidant, and enzyme inhibitory properties, as well as its phenolic and lipophilic compounds.

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Objective: Tumor necrosis factor alpha inhibitors are frequently used in the treatment of axial spondyloarthritis. While tumor necrosis factor alpha is associated with some malignancies, studies on its effects on thyroid functions and thyroid nodules are limited. This study aimed to assess the effect of tumor necrosis factor alpha inhibitors treatments on the evaluation of thyroid nodules and thyroid function tests in axial spondyloarthritis patients.

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Article Synopsis
  • The study investigates the biological properties and chemical profiles of chickweed extracts using various solvents and advanced techniques like UHPLC/MS/MS.
  • Twelve phenolic compounds, primarily flavonoids, were identified, with the water extract showing the best antioxidant capabilities and the ethyl acetate extract showing strong enzyme-inhibiting effects.
  • The findings suggest chickweed could be a valuable resource for developing products in the pharmaceutical, nutraceutical, and cosmeceutical sectors due to its significant cytotoxic effects and potential mechanisms of action against cancer-related targets.
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Purpose: This study aimed to develop the "Sudden Infant Death Syndrome Awareness Scale-Mother Form" (SIDSAS-MF) and assess its psychometric properties.

Design And Methods: The methodological study involved mothers (n = 450) with infants aged 0-12 months. Data were collected using a socio-demographic information form and the draft of the SIDSAS-MF.

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The role of the cerebrovascular system in migraine pathogenesis is critical. Several studies have demonstrated alterations in the regional cerebral blood flow that persist during headache-free intervals. In the present study, we aimed to measure the prefrontal hemodynamic responses to the cognitive task in interictal episodic migraineurs.

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  • This study investigates the active compounds in Chenopodium ambrosioides for their analgesic and antidiabetic properties, motivated by the plant's therapeutic effects.
  • The research utilized gas chromatography-mass spectrometry to analyze various aqueous extracts and fractions, finding several significant chemical families and compounds associated with these properties.
  • In the assays, the ethyl acetate fraction (EAF) displayed the highest α-amylase inhibition, while the infused aqueous macerate (EAM) was the most effective against α-glucosidase, outperforming the standard antidiabetic drug acarbose.
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  • The study investigates the prevalence and risk factors of vertebral fractures (VF) in older adults in The Gambia, highlighting the growing concern as the population ages.
  • Results showed a VF prevalence of 14.8% and an incidence rate of 12.1%, with significant associations found between lower bone mineral density (BMD) and increasing age for both men and women.
  • The findings emphasize the importance of recognizing and addressing vertebral fractures in resource-limited settings, as they present similar risks to those identified in other populations.
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