Prevalence, molecular identification and genotyping of the crayfish plague pathogen, in major narrow-clawed crayfish ( Eschscholtz, 1823) populations from Türkiye.

Introduction: Crayfish plague is considered the most important crayfish disease globally. It is caused by the fungus-like agent, . This study aimed to identify and determine the prevalence of using PCR in narrow-clawed crayfish () populations from across Türkiye.

Effect of Brochure and Audio Recordings of Testicular Cancer Stories on Testicular Self-Examination: Randomized Controlled Study.

Objectives: The aim of this study was to determine the effects of a training program based on educational brochures and audio recordings of testicular cancer (TC) stories on testicular self-examination (TSE) and health beliefs among university students.

Design: The study had a pretest-posttest, control group experimental design.

Sample: This study was conducted with 106 students in Turkey.

Predictive value of nutritional scores in non-valvular atrial fibrillation patients: Insights from the AFTER-2 study.

Background And Aim: Many scoring systems are used to evaluate malnutrition, but there is no consensus on which scoring system would be more appropriate. We aimed to investigate the effect of malnutrition in patients with non-valvular atrial fibrillation (NVAF) and to compare three scoring systems.

Methods And Results: A total of 2592 patients with non-valvular AF from 35 different centers in Turkey were included in this prospective study.

In vitro effect of vitaminB on embyro growth by induction of hypoxia in culture.

In this study, effects of vitaminB on embryonic development have been investigated by supplying vitaminB on a hypoxia-induced embryo culture. 9.5-day-old embryos from Wistar albino adult pregnant rats were used in our experimental set up.

Analysis of Cesarean Section Ratios by Robson Classification.

Background And Aim: Cesarean section (CS) is a delivery method, which is used to avoid the complications of vaginal delivery, maternal and neonatal morbidity, and mortality. It has become the most applied surgical procedure both in Türkiye, and globally. In 2013, Robson et al.

Associations between income level and health outcomes in people with cystic fibrosis in Turkey.

Background: Our study aimed to identify the social domains that pose the greatest barriers to managing and supporting pwCF, particularly in relation to income levels.

Methods: To identify associations between income and health outcomes in pwCF in our center the shorter form of the survey "Your Current Life Situation" (YCLS) was used in face-to-face interviews. Participants were also asked to complete the validated Turkish versions of the 9-item Patient Health Questionnaire (PHQ-9) and the 7-item Generalized Anxiety Disorder scale (GAD-7) to assess depression and anxiety, respectively.

CRISPR-Cas9-Mediated Targeting of Multidrug Resistance Genes in Methicillin-Resistant .

Antibiotic resistance poses a global health crisis limiting the efficacy of available therapeutic agents. We explored CRISPR-Cas-based antimicrobials to combat multidrug resistance in methicillin-resistant (MRSA), targeting methicillin (A), gentamicin (A), and ciprofloxacin (A, B) resistance genes. Engineered CRISPR plasmids with specific single-guide RNAs were electroporated into MRSA strains.

The impact of neuroinflammation on neuronal integrity.

Neuroinflammation, characterized by a complex interplay among innate and adaptive immune responses within the central nervous system (CNS), is crucial in responding to infections, injuries, and disease pathologies. However, the dysregulation of the neuroinflammatory response could significantly affect neurons in terms of function and structure, leading to profound health implications. Although tremendous progress has been made in understanding the relationship between neuroinflammatory processes and alterations in neuronal integrity, the specific implications concerning both structure and function have not been extensively covered, with the exception of perspectives on glial activation and neurodegeneration.

The Association between Aminoglycoside Exposure and Ototoxicity in Children with Cystic Fibrosis.

Introduction: Pulmonary exacerbations increase the requirement of aminoglycoside (AG) antibiotics in people with cystic fibrosis (pwCF). Several studies have shown that AGs have a cumulative effect on ototoxicity. We aimed to investigate the relationship between AG exposure and ototoxicity by using 3 different methods in patients with CF.

Assessment of patients' baseline cystic fibrosis knowledge levels following translation and adaptation of the CF R.I.S.E translation program into Turkish.

Background: Cystic fibrosis (CF) patients have a limited life expectancy, but significant medical advances now highlight the need for successful transition programs from pediatric to adult care. The goal of this project was to introduce the transition program CF R.I.

Experiences of Patients Undergoing Robot-assisted Cardiac Surgery: A Qualitative Study.

Purpose: Over the last two decades, the use of robotic surgery in cardiac procedures has become increasingly prevalent. Typically, assessments of patient outcomes for robot-assisted surgery concentrate on patient morbidity and mortality, surgical complications, and length of hospital stay. However, there is limited research on patients' perceptions of robot-assisted surgery.

Unveiling Off-Target Mutations in CRISPR Guide RNAs: Implications for Gene Region Specificity.

The revolutionary CRISPR-Cas9 technology has revolutionized genetic engineering, and it holds immense potential for therapeutic interventions. However, the presence of off-target mutations and mismatch capacity poses significant challenges to its safe and precise implementation. In this study, we explore the implications of off-target effects on critical gene regions, including exons, introns, and intergenic regions.

Analysis of the relationship between fear of coronavirus and hand hygiene beliefs and practices of surgical nurses: A descriptive and cross-sectional study.

Aim: This study aimed to analyse the relationship between fear of COVID-19 and hand hygiene beliefs and practices of surgical nurses.

Method: This article is a descriptive correlational study. It was conducted between February and May 2021 with 306 surgical nurses working at public and private hospitals in Northern Cyprus.

The protective role of selenium against high-fructose corn syrup-induced kidney damage: a histopathological and molecular analysis.

With the growth of the food industry, fructose, the intake of which increases with food, causes obesity and metabolic syndrome. Kidney damage may develop from metabolic syndrome. Selenium (Se) participates in the structure of antioxidant enzymes and has a medicinal effect.

From cell lines to cancer patients: personalized drug synergy prediction.

Motivation: Combination drug therapies are effective treatments for cancer. However, the genetic heterogeneity of the patients and exponentially large space of drug pairings pose significant challenges for finding the right combination for a specific patient. Current in silico prediction methods can be instrumental in reducing the vast number of candidate drug combinations.

Paracervical block before laparoscopic total hysterectomy: A randomized controlled trial.

Objective: To test the hypothesis that paracervical block with 0.5 % bupivacaine decreases postoperative pain after total laparoscopic hysterectomy (TLH).

Materials And Method: This randomized double-blind placebo control trial included 152 women.

Contraceptive use and sexual quality of life of patients with thalassemia in Northern Cyprus: a descriptive cross-sectional study.

Objective: Although contraception methods are an important factor affecting sexual life, no literature has been recorded about the contraceptive methods used and the sexual life of thalassemia patients. The aim of this study is to document the effects of and preferences of contraception methods used in the sexual lives of patients with thalassemia.

Methods: The descriptive and cross-sectional study took place in Northern Cyprus at a Thalassemia Center in a State Hospital.

Bioactive peptides: an alternative therapeutic approach for cancer management.

Cancer is still considered a lethal disease worldwide and the patients' quality of life is affected by major side effects of the treatments including post-surgery complications, chemo-, and radiation therapy. Recently, new therapeutic approaches were considered globally for increasing conventional cancer therapy efficacy and decreasing the adverse effects. Bioactive peptides obtained from plant and animal sources have drawn increased attention because of their potential as complementary therapy.

Psychometric properties of a Turkish version of the social activities scale for community-dwelling older people requiring support.

Background: Social activities decelerate the deterioration of mental capacity in older people and improve their physical and psychosocial health. Valid and reliable measurement tools are needed to determine the social activity status of older people and plan health services to protect their mental health.

Objective: This study aimed to adapt the Social Activities Scale for Community-Dwelling Older People Requiring Support (SASOS) into Turkish.