Optic Nerve Head Changes in Acute Central Serous Chorioretinopathy: Implications for Glaucoma Risk.

Objective: Imaging techniques have demonstrated changes in the choroid and retina in acute central serous chorioretinopathy (CSCR), but the effects on the optic nerve head (ONH) remain unclear. This study investigates ONH structural changes in acute CSCR using enhanced deep imaging optic coherence tomography (EDI-OCT).

Methods: A prospective cohort study included 51 acute CSCR patients and 51 healthy controls aged 18-65 years.

Factors related to the decision to perform synchronized cardioversion for supraventricular tachyarrhythmias by prehospital emergency medical services workers.

Background: While clinical indicators for synchronized cardioversion in regular supraventricular tachycardias are well-established, their application by prehospital emergency medical services (EMS) still needs to be explored.

Objective: The purpose of this study was to evaluate the factors influencing the decision-making process of prehospital EMS personnel to perform synchronized cardioversion in adults with narrow QRS regular tachyarrhythmias.

Methods: This descriptive study included 598 paramedics actively engaged in prehospital EMS.

Comparative Analysis of Cosmetic and Functional Outcomes in Corneal Tattooing (Keratopigmentation) versus Ocular Prosthesis.

Objectives: This study compares the cosmetic and functional outcomes of corneal tattooing/keratopigmentation and ocular prostheses in rehabilitating disfigured eyes, focusing on esthetic appearance and emotional well-being.

Methods: Ninety-two patients were included: 48 received corneal tattooing, and 44 were fitted with ocular prostheses. Anophthalmic surgery was indicated for trauma, painful blind eye, endophthalmitis, tumor, and corneal ulcer, while corneal tattooing was performed for trauma, corneal ulcer, and endophthalmitis.

Synthesis, characterization, and investigation of photochemical and in vitro properties of novel Zn(II) phthalocyanine.

A new nonperipheral zinc(II) phthalocyanine bearing octa carboxylic acid ethyl ester derivative substituted triazole attached propylmercaptothiobenzylmercapto derivative was synthesized via the tetramerization reaction of phthalonitrile. The photochemical in vitro photodynamic activity of zinc(II) phthalocyanine (), such as human nonsmall cell lung carcinoma cell lines, was investigated in this study. The singlet oxygen generation property of novel zinc(II) phthalocyanine () was also examined due to the significantly high singlet oxygen quantum yield of (F = 0.

Interplay of NF-κB and PPAR-γ transcription factors in patients with juvenile systemic lupus erythematosus.

Objective: Juvenile SLE (jSLE) is an autoimmune disease characterised by the presence of high levels of autoantibodies, predominantly targeting nuclear antigens, resulting in a breakdown of self-tolerance. However, its pathogenesis is multifactorial and poorly understood. The aim of this study was to evaluate the potential of nuclear factor-kappa B (NF-κB) and peroxisome proliferator-activated receptor-gamma (PPAR-γ) as biomarkers for jSLE.

miR-21 and cathepsin B in familial Mediterranean fever: novel findings regarding their impact on disease severity.

Objective: The limited predictive effect of genotype on familial Mediterranean fever (FMF) phenotype suggests that epigenetic factors and alternative mechanisms that may cause IL-1β release could contribute to phenotypic heterogeneity. The objective of this study was to examine the role of IL-1β levels and miR-21-5p, cathepsin B and pyrin levels, which were identified as potential factors causing IL-1β release through the use of bioinformatics tools, in the pathogenesis of FMF and their relationship with disease severity.

Materials And Methods: 50 paediatric patients with FMF and 40 healthy children were enrolled in this study.

Is obstructive sleep apnea syndrome a risk factor for floppy eyelid syndrome? A multicenter study.

Objective: Evaluate the relationship between OSAS and floppy eyelid syndrome [FES], along with possible confounding factors such as gender, age, and BMI.

Methods: This was a multicenter, cross-sectional prospective study. Patients referred to the sleep clinic suspected of OSAS were included in the study.

Comparative analysis of PECS-2 and ESP for acute and chronic pain control in breast-conserving surgery. A prospective study.

Objective: The aim of this study was to compare the effects of Pectoral Nerve Block 2 (PECS-2) and Erector Spinae Plane Block (ESP), which are accepted to have an effect on post-operative pain control after breast cancer surgery, on both acute and chronic pain.

Method: In this double-blind, prospective, randomized study, patients were randomized using a sealed envelope method into two groups: those who underwent PECS-2 (Group P) and those who underwent ESP (Group E) before extubation at the end of the operation. The numerical rating scale (NRS) of patients was queried by a blinded researcher at post-operative 1, 2, 6, 12, and 24 h.

Delineating the genetic landscape of Charcot-Marie-tooth disease in Türkiye: Distinct distribution, rare phenotypes, and novel variants.

Background: Charcot-Marie-Tooth (CMT) disease is the most common inherited neuropathy. In this study, we aimed to analyze the genetic spectrum and describe phenotypic features in a large cohort from Türkiye.

Methods: Demographic and clinical findings were recorded.

Intramedullary Schwannoma in the Cervical Region: A Case Report.

Intramedullary schwannomas are a type of benign spinal cord tumor that originates from the Schwann cells of the nerve sheath. They are relatively rare and typically occur within the spinal cord itself, rather than in the surrounding tissue. Treatment options for cervical intramedullary schwannomas include surgical removal of the tumor, radiation therapy, and observation.

Does smartphone addiction impact happiness? exploring the mediating roles of belongingness and fear of missing out: a cross-sectional survey from Turkey.

The aim of the study is to determine whether the fear of missing out (FoMO) has a mediating role in the effect of general belongingness (acceptance, exclusion) and happiness on smartphone addiction. The study consists of 656 university students from Turkey and agreeing to participate in the study. Of the students participating in the study, 77.

Investigation of the Effects of Ozon and Propolis on the Healing of Bone Defects: An Experimental Study.

Background/aim: This study explores the effects of ozone and propolis on the healing of critically sized bone defects at both the histologic and molecular levels, and the locations and concentrations of osteopontin and osteonectin during healing; both proteins play roles during bone healing.

Materials And Methods: This study used 56 adult male Sprague-Dawley rats of an average weight of 350 g, divided into four groups of 14: a control group, a topical ozone group (O), a topical ozone + systemic propolis (O + PO) group, and a systemic propolis group (PO). Seven rats from each group were sacrificed at the end of week 4 and the other seven at the end of week 6.

Balance in children with chronic kidney disease: the relationship between skeletal muscle mass index, fatigue, and physical function.

Background: The study evaluated the relationship between balance function and skeletal muscle mass index (ASMI), physical function, and fatigue in children with chronic kidney disease (CKD).

Methods: A cross-sectional study of 83 children with CKD (stages 1-4, dialysis, transplant) and 71 healthy controls was conducted. Functional performance tests, including gait speed, 6-min walk distance (6MWD), five-repetition sit-to-stand (5RST), and timed up-and-go (TUG) tests, were administered.

Recovery, Bioactivity, and Utilization of Bioactive Phenolic Compounds in Peel.

peels are rich in bioactive phenolic compounds with various health effects including antioxidant, antiobesity, antiinflammatory, antihypertensive, antihypercholesterolemic, antimicrobial, antidiabetic, and anticarcinogenic activities. Both extractable and nonextractable phenolics are present in significant amounts in peel with diverse bioactivities. While extractable phenolics can be recovered from the fruit peels by conventional extraction methods, nonextractable phenolics remaining in the residues must be released from the cell matrix first by hydrolysis with acid, alkali, or enzymes.

One Receptor Show: Evaluation of Feature Extraction Methods for a Single Gas Sensor Based on α-Tocopherol-Substituted Zinc Phthalocyanine.

A consistent part of gas sensor research activities aims to improve sensing performances by synthesizing new sensing materials, improving the selection of elements in arrays, and optimizing the feature extraction and classification algorithms. This paper combines most of these aspects to confer selectivity to a low-selectivity sensor by using feature extraction algorithms applied to the sensor response kinetics. Several algorithms were employed to represent the kinetic behavior of the sensor response during the adsorption and desorption phases.

External Validation of Vision, Aphasia and Neglect, Ventura Emergent Large Vessel Occlusion and Large Artery Intracranial Occlusion Screening Tools for Emergent Large Vessel Occlusion Stroke: A Multicenter, Prospective, Cross-Sectional Study.

Background: Vision, Aphasia, and Neglect (VAN), Ventura Emergent Large Vessel Occlusion (VES), and Large Artery Intracranial Occlusion (LARIO) are promising stroke screening tools that were shown to have high diagnostic performance to detect Emergent Large Vessel Occlusion (ELVO) in their derivation studies.

Objectives: This study aimed to assess the validation of VAN, VES, and LARIO in predicting ELVO among patients presenting at emergency department (ED) triage with suspected acute ischemic stroke.

Methods: This is a prospective multicenter study conducted in five EDs of tertiary stroke centers between June and October 2023.

The influence of digital literacy on mHealth app usability: The mediating role of patient expertise.

Objective: Mobile health (mHealth) applications are emerging as important healthcare technologies that can provide cost savings, better access to care, contribute to improved clinical outcomes, and support public health. An increasing number of mobile health (mHealth) applications are becoming available to download and use on mobile devices. However, unlocking this potential requires ensuring widespread acceptance and adoption of these applications.

Dysfunction of PTEN-Associated MicroRNA Regulation: Exploring Potential Pathological Links in Type 1 Diabetes Mellitus.

Type 1 Diabetes Mellitus (T1DM) is an autoimmune disease with T cell-mediated pathogenesis of pancreatic β-cell destruction, leading to insulin deficiency. MicroRNAs such as miR-223 and miR-106b, along with PTEN, have been reported to participate in the pathophysiology of diabetes and its complications. The current study has explored the expression of miR-223, miR-106b, and PTEN and their association with various clinical and biochemical parameters in subjects diagnosed with T1DM.

Relationship between NLR (Neutrophil/Lymphocyte ratio) value and clinical outcome in patients with external ventricular drainage due to intraventricular hemorrhage.

Background: Intraventricular hemorrhages (IVH) are common pathologies in neurosurgery practice and are associated with the worst clinical outcome among all intracranial hemorrhages. Blood in the ventricles is thought to worsen the clinical condition by triggering inflammatory processes. In recent years, NLR value is a frequently used inflammatory parameter, and there are many publications reporting that a high NLR value is an important marker in predicting the severity of inflammation.

Mesothelioma Cases in the World Trade Center Survivors.

Objectives: The destruction of the World Trade Center (WTC) towers in New York City on September 11, 2001 (9/11), released approximately 1 million tons of pulverized particulate matter throughout southern Manhattan and areas in Brooklyn, exposing community members and responders to high levels of potentially toxic environmental particles. Asbestos exposure was a health concern because of its use in certain sections of the WTC towers. Malignant mesothelioma, originating from the lining cells (mesothelium) of the peritoneal and pleural cavities, is one complication associated with asbestos exposure.