Comparative analysis of TNF-α (-308) gene polymorphism in Turkish patients with type 2 diabetes developing nephropathy and/or neuropathy.

Type 2 diabetes (T2DM) is a group of chronic and systemic metabolic diseases. Nephropathy (NP) and neuropathy (NR) are two common complications that severely affect the quality of life of patients with T2DM. In this study, our aim was to investigate the association between TNF-alpha (-308) gene polymorphism and the risk of developing NP and NR in patients with T2DM We also aimed to determine the association between TNF-alpha (-308) gene polymorphism and several demographic characteristics and biochemical parameters of patients with T2DM developed NP and/or NR.

Comparison of the effect of general anesthesia and combined epidural anesthesia on the anesthetic management of gynecological oncological surgery.

Objective: To evaluate the potential advantages of combined general and epidural anesthesia for major gynecological oncological surgeries.

Materials And Methods: The data of 690 gynecological cancer were retrospectively examined, and 223 patients who met the inclusion criteria were included in the study. The patients were divided into two groups: Group G (123 patients who received general anesthesia only) and Group C (100 patients who received combined epidural and general anesthesia.

Can hazelnut flour added to gluten-free corn flour in different amounts cause differences in blood glucose fluctuations?

Aims to find out how adding different amounts of hazelnut to corn flour affects women's blood glucose fluctuations. Women ( = 23) were given loaves of bread containing corn and hazelnut flour (50 g digestible CHO). They were given 50 g of glucose syrup to consume in the first week, normal corn-bread (CB) in the second week, 15 g of corn-bread with hazelnut flour (CB + 15HN) in the third week and 30 g of corn-bread with hazelnut flour (CB + 30HN) in the fourth week.

Retrospective evaluation of postoperative analgesia efficacy of a new technique in anterior iliac crest bone graft harvesting: anterior iliac block.

Background: In reconstructive surgeries, iliac crest bone graft harvesting is commonly preferred. The pain experienced after surgery at the anterior iliac crest (AIC) donor site might be more intense compared to the pain at the primary surgical area where the graft is placed. To address this issue, we defined a novel technique called the anterior iliac block (AIB), which can provide analgesia with lower volumes.

Effect of Vitamin D Supplementation According to Daily Dietary Levels on Biochemical Parameters in 25-Hydroxyvitamin D Deficiency of Women with Obesity.

Objectives: This study examined how vitamin D supplementation based on daily dietary intake affects biomarkers in obese women with 25-hydroxyvitamin D deficiency.

Materials And Methods: Group D (n= 14) used vitamin D supplements daily for 2 months, and Group C (n= 16) did not receive supplements. Three blood samples were collected from the volunteers during the initial phase of the study.

Defective kinase activity of IKKα leads to combined immunodeficiency and disruption of immune tolerance in humans.

IKKα is a multifunctional serine/threonine kinase that controls various biological processes, either dependent on or independent of its kinase activity. However, the importance of the kinase function of IKKα in human physiology remains unknown since no biallelic variants disrupting its kinase activity have been reported. In this study, we present a homozygous germline missense variant in the kinase domain of IKKα, which is present in three children from two Turkish families.

Comparative Proteomics Highlights that GenX Exposure Leads to Metabolic Defects and Inflammation in Astrocytes.

Exposure to PFAS such as GenX (HFPO dimer acid) has become increasingly common due to the replacement of older generation PFAS in manufacturing processes. While neurodegenerative and developmental effects of legacy PFAS exposure have been studied in depth, there is a limited understanding specific to the effects of GenX exposure. To investigate the effects of GenX exposure, we exposed to GenX and assessed the motor behavior and performed quantitative proteomics of fly brains to identify molecular changes in the brain.

A benchmark of RNA-seq data normalization methods for transcriptome mapping on human genome-scale metabolic networks.

Genome-scale metabolic models (GEMs) cover the entire list of metabolic genes in an organism and associated reactions, in a tissue/condition non-specific manner. RNA-seq provides crucial information to make the GEMs condition-specific. Integrative Metabolic Analysis Tool (iMAT) and Integrative Network Inference for Tissues (INIT) are the two most popular algorithms to create condition-specific GEMs from human transcriptome data.

Examination of diet quality and alcohol on serum IgG levels after first and second COVID-19 vaccines.

Rationale: The change of IgG of COVID-19 vaccine was thought to be an effect of diet quality or daily habits.

Aims And Objectives: This study aimed to correlate diet quality and healthy living factors with serum IgG response in the blood.

Methods: Participants were selected from volunteers who had their first vaccination and did not have COVID-19 disease (Male = 21 Female = 40).

The Diagnostic Performance of Large Language Models and General Radiologists in Thoracic Radiology Cases: A Comparative Study.

Purpose: To investigate and compare the diagnostic performance of 10 different large language models (LLMs) and 2 board-certified general radiologists in thoracic radiology cases published by The Society of Thoracic Radiology.

Materials And Methods: We collected publicly available 124 "Case of the Month" from the Society of Thoracic Radiology website between March 2012 and December 2023. Medical history and imaging findings were input into LLMs for diagnosis and differential diagnosis, while radiologists independently visually provided their assessments.

In silico evaluation of corneal patch eluting anti-VEGF agents concept.

This study introduces a novel approach utilizing a temporary drug-eluting hydrogel corneal patch to prevent neovascularization, alongside a numerical predictive tool for assessing the release and transport kinetics of bevacizumab (BVZ) after the keratoplasty. A key focus was investigating the impact of tear film clearance on the release kinetics and drug transport from the designed corneal patch. The proposed tear drug clearance model incorporates the physiological mechanism of lacrimal flow (tear turnover), distinguishing itself from previous models.

Evaluating text and visual diagnostic capabilities of large language models on questions related to the Breast Imaging Reporting and Data System Atlas 5 edition.

Purpose: This study aimed to evaluate the performance of large language models (LLMs) and multimodal LLMs in interpreting the Breast Imaging Reporting and Data System (BI-RADS) categories and providing clinical management recommendations for breast radiology in text-based and visual questions.

Methods: This cross-sectional observational study involved two steps. In the first step, we compared ten LLMs (namely ChatGPT 4o, ChatGPT 4, ChatGPT 3.

Can large language models be new supportive tools in coronary computed tomography angiography reporting?

The advent of large language models (LLMs) marks a transformative leap in natural language processing, offering unprecedented potential in radiology, particularly in enhancing the accuracy and efficiency of coronary artery disease (CAD) diagnosis. While previous studies have explored the capabilities of specific LLMs like ChatGPT in cardiac imaging, a comprehensive evaluation comparing multiple LLMs in the context of CAD-RADS 2.0 has been lacking.

Saline cleansing can prevent infective complications after transrectal prostate biopsy: A randomized prospective study.

Purpose: To discern whether reduced infection rates were attributed to antiseptic solutions or mechanical rectal irrigation.

Patients And Methods: After receiving ethical approval, the study included patients who underwent transrectal prostate biopsy due to elevated PSA or abnormal digital rectal examination findings, and prostate cancer under active surveillance, at Tepecik Training and Research Hospital between April 2022 and June 2023. Standard antibiotic prophylaxis was administered.

Comparison of Performance of Large Language Models on Lung-RADS Related Questions.

This study evaluates LLM integration in interpreting Lung-RADS for lung cancer screening, highlighting their innovative role in enhancing radiological practice. Our findings reveal that Claude 3 Opus and Perplexity achieved a 96% accuracy rate, outperforming other models.

Evaluation of neck ultrasound measurements as a difficult airway predictor: A prospective observational study.

This study aimed to investigate the relationship between cervical measurements and difficult airways using ultrasonographic measurements. American Society of Anesthesiologists grade I to III, male or female, 120 adult patients, undergoing elective surgery were enrolled in the study. The study involved measuring the distance of the trachea, cricoid cartilage, thyroid cartilage, vocal cord anterior commissure, and hyoid bone to the skin using a 10 to 13 MHz linear ultrasound probe in the transverse plane.

Fabrication of bacterial cellulose/PVP nanofiber composites by electrospinning.

This study aimed to address a significant challenge in the application of bacterial cellulose (BC) within tissue engineering and regenerative medicine by tackling its inherent insolubility in water and organic solvents. Our team introduced a groundbreaking approach by utilizing zinc sulfate (ZnSO) as a solvent to render BC soluble, a novel contribution to the literature. Subsequently, the obtained soluble BC was combined with varying concentrations of polyvinylpyrrolidone (PVP).