Cryopreservation and assessment of Honamli and Hair buck semen using resveratrol.

Background: Resveratrol (Res) (3,5,4'-trihydroxystilbene) is a natural polyphenol that exhibits important biological activities.

Objective: To assess the effects of resveratrol (Res) on freeze-thawed survival of semen from Honamli and Hair Bucks.

Materials And Methods: Six bucks, aged 2-3 years (three from each breed), were included in the study.

Prevalence and incidence of neuromyelitis optica spectrum disorder in Türkiye: A nationwide epidemiologic study.

Background: Epidemiological studies of neuromyelitis optica spectrum disorder (NMOSD) show variability due to differences in methodologies, diagnostic criteria, and geographic factors.

Objective: This study aimed to determine NMOSD's epidemiological profile in Türkiye using official health records covering over 95 % of the population.

Methods: Data were collected using ICD-10 codes (G36.

Constrained optimization: evaluating possible packages of community health interventions with competing resource requirements in Galmudug, Somalia.

Investment in Community Health Worker (CHW) programs has allowed health systems to reach previously underserved rural and remote populations. As a result, CHWs are often burdened with responsibilities to deliver large packages of services, at times without sufficient human, financial, or health resources. To design a community-level program that saves maternal and newborn lives while operating within resource limitations, we used constrained optimization (a mathematical process for finding the solution to a stated objective while accounting for listed requirements) to construct a model for select villages in Galmudug State, Somalia.

Impact of sympathetic denervation via paraaortic lymphadenectomy on blood pressure in endometrial cancer patients.

Objective: To evaluate the effect of para-aortic lymphadenectomy on blood pressure changes in endometrial cancer patients.

Materials And Methods: This retrospective study included patients with endometrial cancer treated surgically between 2017 and 2023. Patients undergoing para-aortic lymphadenectomy, up to the renal artery, in a non-nerve-sparing fashion, were compared with those undergoing pelvic lymphadenectomy or sentinel lymph node mapping.

The effect of basic need dissatisfaction and lack of social support on problematic Internet use in emerging adults: The mediating role of regulatory emotional self-efficacy.

The purpose of this research is to explore the mediating role of regulatory emotional self-efficacy in the relationship between dissatisfaction basic psychological needs, lack of social support on problematic Internet use among emerging adults. The study sample comprises 436 emerging adults (mean age = 22.42, SD = 2.

Impact of Trolox Supplementation on the Cryopreservation of Honamli Buck Semen.

Cryopreservation of buck semen is essential in animal breeding but often damages sperm viability and integrity. The Honamli breed, a hardy Turkish goat, can benefit from improved freezing techniques using antioxidants such as Trolox (T). This study explores the effects of varying T concentrations on Honamli buck semen, assessing parameters such as motility, viability, and membrane integrity to enhance post-thaw quality.

Predictors of stages of adoption of colorectal cancer screening among adults attending primary healthcare centers in Turkey.

Background: Despite the proven effectiveness of colorectal cancer (CRC) screening in reducing mortality, adherence rates for fecal occult blood testing (FOBT) and colonoscopy remain low among Turkish adults. This study aimed to assess the stages of adoption of CRC screening behaviors, identify the factors influencing adoption, and examine the perceived benefits and barriers to screening.

Methods: A cross-sectional study was conducted in Istanbul's Anatolian region from May to June 2022, involving 498 adults aged 50-70 years.

The efficacy of interferential current treatment on knee osteoarthritis: A pilot randomized double-blind study comparing the effects of different carrier frequencies.

Objectives: This study aimed to investigate the effects of different carrier frequencies of interferential current (IFC) treatment on a Visual Analog Scale (VAS) for pain, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), 10-m walk test, and the amount of paracetamol taken.

Patients And Methods: The double-blind, randomized controlled study included 61 patients (16 males, 45 females; mean age: 63.7±9.

Maternal N-acetylcysteine supplementation in lactation ameliorates metabolic and cognitive deficits in adult offspring exposed to maternal obesity.

Maternal obesity in pregnancy and lactation is linked to metabolic disturbances and neurodevelopmental problems in offspring, increasing the risk of psychiatric disorders in adulthood. We proposed that maternal N-acetyl cysteine (NAC) supplementation during lactation, a critical period for neurodevelopment, potentially protects offspring from developing cognitive impairment in adulthood. Fifteen young female ICR mice were randomly allocated to different experimental groups: high-fat diet (HFD; 60.

Enhanced object detection in remote sensing images by applying metaheuristic and hybrid metaheuristic optimizers to YOLOv7 and YOLOv8.

Developments in object detection algorithms are critical for urban planning, environmental monitoring, surveillance, and many other applications. The primary objective of the article was to improve detection precision and model efficiency. The paper compared the performance of six different metaheuristic optimization algorithms including Gray Wolf Optimizer (GWO), Particle Swarm Optimization (PSO), Genetic Algorithm (GA), Remora Optimization Algorithm (ROA), Aquila Optimizer (AO), and Hybrid PSO-GWO (HPSGWO) combined with YOLOv7 and YOLOv8.

Development of an Oxygen-Insensitive Nrf2 Reporter Reveals Redox Regulation under Physiological Normoxia.

Reactive oxygen species, particularly hydrogen peroxide (HO), play crucial roles in cellular signaling, with Nrf2 serving as a key transcription factor in maintaining redox homeostasis. However, the precise influence of HO on Nrf2 activity under physiological normoxia remains unclear due to the limitations of oxygen-sensitive imaging methods. To address this, we developed and validated an oxygen-insensitive Nrf2 reporter named pericellular oxygen-insensitive Nrf2 transcriptional performance reporter (POINTER).

Clinical Significance of Sarcopenia Defined by the Cross-Sectional Area of the Masseter Muscle in Cerebrovascular Events: A Retrospective Cohort Study.

: This study aimed to investigate the clinical significance of sarcopenia, defined by the cross-sectional area of the masseter muscle (CSA-M), as an early marker for sarcopenia diagnosis and its association with mortality in patients with cerebrovascular events (CVE). In this retrospective cohort study, 120 patients aged 65 years or older with CVE admitted to Bilkent City Hospital between September 2020 and September 2023 were included. Patients with malignancy, prior CVE, or incomplete data were excluded.

Predicting Mortality in Subarachnoid Hemorrhage Patients Using Big Data and Machine Learning: A Nationwide Study in Türkiye.

Subarachnoid hemorrhage (SAH) is associated with high morbidity and mortality rates, necessitating prognostic algorithms to guide decisions. Our study evaluates the use of machine learning (ML) models for predicting 1-month and 1-year mortality among SAH patients using national electronic health records (EHR) system. Retrospective cohort of 29,274 SAH patients, identified through national EHR system from January 2017 to December 2022, was analyzed, with mortality data obtained from central civil registration system in Türkiye.

Prevalence of Japanese encephalitis in pigs in Mainland China during 2000-2024: a systemic review and meta-analysis.

Background: Japanese encephalitis (JE) is an acute viral disease transmitted mainly by mosquitoes, primarily affecting Southeast Asia, and the Western Pacific. This study aimed to analyze the factors contributing to JE occurrence in pigs across China.

Methods: A systematic search was done using six databases for the published epidemiological studies on porcine JE, including the Chinese Web of Knowledge (CNKI), Wan Fang Database, ScienceDirect, Web of Science, VIP Chinese Journal Database, and PubMed.

Successful Management of Post-Thymectomy Pure Red Cell Aplasia with Rituximab: A Case Report.

Background: Pure red cell aplasia (PRCA) is a rare cause of anemia characterized by decreased red blood cell production, often associated with thymomas. While thymectomy is commonly performed to treat thymoma-associated PRCA, the development of PRCA post-thymectomy is less understood.

Case Presentation: We present a case of a 25-year-old woman who developed PRCA and autoimmune diabetes mellitus (DM) following radical thymectomy for malignant thymoma.

Engineering Komagataella phaffii for citric acid production through carbon-conserving supply of acetyl-CoA.

The oxidative formation of AcCoA limits the glycolytic pathway yield (Y) for citric acid due to the NADH overflow and carbon loss as CO. An interesting approach to enhance product yields is the incorporation of carbon-conserving pathways. This study assesses the potential of a carbon-conserving AcCoA pathway, the glycolysis alternative high carbon yield cycle (GATHCYC), to improve citric acid production, utilizing the non-native citric acid producer Komagataella phaffii as an orthogonal test system.

Alternative approach to monitoring labor: purple line.

Background: Current methods used to assess the progress of labor are often invasive and may cause discomfort to the mother. The purple line offers potential as a non-invasive marker for monitoring the labor process. However, its sensitivity and specificity in assessing critical components of labor, such as cervical dilatation and fetal descent, have not been adequately studied in different populations.

Does transitioning to a dual surgeon approach improve outcomes for posterior spinal fusion of adolescent idiopathic scoliosis and neuromuscular scoliosis?

Study Design: Retrospective, chart review.

Purpose: Improvements in operative time, blood loss, and length of stay (LOS) when using a dual surgeon approach for the treatment of scoliosis have been suggested in the literature; however, the external validity of these findings has been debated. In this study, we examined the impact of transitioning from a single surgeon to a dual surgeon approach in the treatment of adolescent idiopathic scoliosis (AIS) and neuromuscular scoliosis (NMS) across non-contemporary periods at a single institution.

The ART-ET screening tool: an easy-to-use non-invasive screening method to predict difficult embryo transfers in advance.

Study Question: What is the diagnostic performance of the ART-ET screening tool, an easy-to-use non-invasive screening tool for prediction of difficult embryo transfers?

Summary Answer: A simple scoring of transvaginal ultrasound examination of the cervical canal can predict difficult embryo transfers with high specificity, positive likelihood ratio, and accuracy; the inclusion of cervical position and history of cesarean without a vaginal delivery improved predictive performance.

What Is Known Already: Difficult embryo transfer procedures are associated with significantly lower clinical pregnancy and live birth rates, and some interventions may facilitate an anticipated difficult embryo transfer.

Study Design, Size, Duration: A diagnostic test study prospectively conducted on 239 single euploid blastocyst transfer procedures between March and December 2023.

THE EFFECTS OF NEUROMUSCULAR ELECTRICAL STIMULATION ADJUNCT TO LUMBAR STABILIZATION EXERCISES ON MULTIFIDUS MUSCLE THICKNESS, PAIN, DISABILITY, AND PSYCHOSOCIAL STATUS IN PATIENTS WITH CHRONIC LOW BACK PAIN.

Objective: To assess the effects of neuromuscular electrical stimulation combined with lumbar stabilization exercises on lumbar multifidus muscle thickness, disability, pain, depression, anxiety, and fear-avoidance beliefs in patients with chronic low back pain; and to examine the correlation between ultrasound and magnetic resonance imaging of the lumbar multifidus.

Design: Forty patients aged 18-65 years were randomized into two groups: Group 1: exercise and Group 2: exercise + neuromuscular electrical stimulation. The participants underwent 15-session electrical stimulation and/or exercise (3 days/week).