Publications by authors named "Budowski C"
Early tolerability of Comirnaty vaccine in patients with chronic neurological diseases.
Rev Neurol (Paris)
December 2021
Patients with chronic neurological diseases may have predisposing risk factors for severe COVID-19 and should be considered as priority candidates for SARS-CoV-2 vaccination. Nevertheless, the safety of RNA vaccine was evaluated in healthy volunteers or in patients with stable chronic medical conditions excluding patients with chronic neurological diseases. We report here the early tolerability of Comirnaty vaccine in 36 patients with chronic neurological diseases and demonstrate good early tolerability, better than found in healthy people in phase 3 trials.
View Article and Find Full Text PDFArticle Synopsis
- Primary familial brain calcification (PFBC) is a rare neurogenetic disorder caused by mutations in several genes, including MYORG, which leads to a distinct autosomal recessive inheritance pattern.
- A study identified 11 families with MYORG mutations, observing severe clinical symptoms such as motor impairment and dysarthria, with patients showing a median onset age of 52 years.
- MYORG patients demonstrated more severe brain calcification patterns, including unique brainstem calcifications not seen in autosomal dominant PFBC cases, and all patients exhibited varying degrees of cerebellar atrophy.