[DYNAMICS OF METABOLIC CHARACTERISTICS, MARKERS OF OXIDATIVE STRESS AND VASCULAR WALL DAMAGE DURING TREATMENT OF OBESE PRE-DIABETIC PATIENTS].

We studied lipid and carbohydrate metabolism, markers of oxidative stress (plasma malonic dialdehyde and dienoic conjugates) and vascular wall damage (CRP microalbuminuria, blood desquamated endotheliocytes) before and after 12 week treatment of obese pre-diabetic patients. The study showed positive dynamics of the above metabolic parameters with normalization of carbohydrate metabolism in 60% of the patients and angioprotective effect of prescribed therapy. The proposed treatment can be used to prevent diabetes mellitus.

Does mycophenolate mofetil increase the incidence of infections in renal transplant recipients?

The aim of this study was to investigate infectious complications in renal transplant recipients (RTRs) receiving mycophenolate mofetil (MMF) for prevention of acute transplant rejection. A group of RTRs (n = 47) receiving 1.0-2.

[Outpatient diagnosis of oxidant stress in patients with carbohydrate metabolism disturbance in metabolic syndrome].

Aim: To compare lipid peroxidation (LPO), (NO)-endothelium system in disorders of glucose tolerance (DGT) in patients with metabolic syndrome (MS) and diabetes mellitus type 2 (DM2).

Material And Methods: The trial included 178 patients with DGT and DM2 within MS (WHO, 1999). The control group consisted of 40 healthy subjects free of MS.

[Infectious complications in using mofetil micofenolate in patients with renal allotransplant].

Aim: To study infectious complications in renal transplant recipients receiving mycophenolate mofetil (MMF) for prevention of acute transplant rejection or treatment of chronic allograft nephropathy (CAN).

Material And Methods: A group of renal transplant recipients (n=47) receiving 1.0-2.

[Diagnostics of disorders in lipid and carbohydrate metabolism in women with hypertension in outpatient clinic].

Aim: To study lipid and carbohydrate metabolism in young and middle-aged women with essential hypertension (EH).

Material And Methods: Anthropometric parameters, arterial pressure (AP), glucose tolerance (GT), fasting glucose, immunoreactive insulin (IRI), glycosylated hemoglobin (HbA1), total cholesterol (TC), triglycerides (TG), HDLP cholesterol, atherogenic index were estimated in 93 women aged 20 to 50 years with EH stage II.

Results: TC was elevated in 75%, HDLP cholesterol--in 52%, TG--in 40% patients.

[A place of outpatient screening in the formation of a current organizational scheme for better radical detection of breast cancer].

The authors consider it necessary to revise the current views of breast cancer in women. In their opinion, excessive consideration of mammography as an independent section of radiation diagnosis does not contribute to better detection of breast cancer. The principle of including mammography into the general traditional section of current radiation diagnosis should be regarded as of paramount importance.

[Outpatient screening and its place in better detection of breast tumors].

The authors state their opinion on this problem by analyzing their 5-year use of their programme specially developed for detection of breast disease, mainly cancer, among females visiting specialized rooms of non-mammological profiles (gastroenterology, endocrinology, rheumatology, pulmonology, neurology, cardiology, hematology, nephrology, etc.) in the consulting polyclinics of regional (territorial) hospitals and large city hospital-polyclinic complexes. In this period, mammographic studies were made in 9169 women included into a breast cancer-risk group.

[Screening diagnosis of breast cancer].

The authors propose their screening program for detection of breast cancer. It includes the entire complex of present-day screening diagnostic methods, starting from an original system for the formation of groups at risk of breast cancer and completed by the direct diagnostic model of detection of the condition, oriented at a differentiated approach to the use of mammographic techniques. The proposed organizational and methodologic screening measures are both economic and diagnostically effective, thus meeting the principal requirements to screening programs.

[Potentialities of x-ray diagnosis in improving the diagnosis of oncologic diseases in outpatient clinics].

The authors analyze the possibilities of improving the prehospital diagnosis of the most prevalent oncologic diseases (tumors of the lungs, stomach, large intestine, mammary gland) that may be effectively detected by modified methods of x-ray and x-ray fluorographic examinations. The x-ray diagnostic service of health centers is regarded as a most important component in the system of prehospital diagnosis. A program of reorganization of this service is suggested, that will help reorient its activities to purposeful screening examinations that will altogether improve the detection of a number of oncologic diseases.