[Effects of thymalin on blood coagulation and contents of proinflammatory and anti-inflammatory cytokines in patients with burns].

The authors share their experiences with treatment of 32 patients with burns of the III-IV degrees using an immunomodulator Thymalin which promoted liquidation of the syndrome of disseminated intravascular coagulation, normalization of fibrinolysis, influenced the content of pro-inflammatory and anti-inflammatory cytokins. It allowed to shorten the terms of the first autodermoplasty at an average by 5 days and to make staying of burned patients at the hospital 11 days shorter.

[The effect of thymalin on indices of immunity and hemostasis in patients with disseminated forms of psoriasis].

Use of thymalin in combined therapy of psoriasis patients has resulted in normalization (complete or incomplete) of the immunity and hemostasis parameters; this has been parallelled by improvement of the clinical status of the patients.

[Use of thymalin and heparin in acute peritonitis].

Results of the investigation of parameters of cell and humoral immunity and coagulogram in 63 patients with acute peritonitis have shown that thymalin when used solely or in combination with heparin facilitates quicker arrest of the pathological process, its clinical and laboratory symptoms. The combination of thymalin and heparin is indicated to elderly patients and in cases with higher risk of thromboformation.

[Effect of thymalin on the status of immunogenesis and hemostasis in patients with ischemic heart disease].

It was established that the use of thymalin in multimodality therapy of CHD patients suffering from attacks of angina pectoris of effort and at rest brought back to normal the state of cellular and humoral immunity, slowed down blood coagulation, decreased fibrinogen and FDP concentration, enhanced total euglobulin and Hageman-dependent fibrinolysis. A more rapid disappearance of the pain syndrome was noted in these patients as compared to those who had not received the drug.

[Use of thymalin in the complex treatment of frostbite].

The use of thymalin in the complex therapy of 19 patients with frostbites was shown by the authors to promote the stimulation of cell immunity, decrease the intensity of intravascular blood coagulation, to increase fibrinolysis, to improve the development of reparative processes in the wound and outcomes of autoplasty. It also decreased the percentage of infectious complications.

[Thymalin as a modulator of immunogenesis and hemostasis].

Studies made in 30 patients with periodontosis have shown that thymaline improves the general health status of patients, thereby promoting the normalization of cellular and, to a lesser degree, humoral immunity. At the same time the drug normalizes blood coagulation, the total and Hageman factor-dependent fibrinolysis. It is concluded that thymaline is a modulator of the immunogenesis and hemostasis.

[Blood coagulability and heart activity on intravenous thrombin administration].

It was shown in dog experiments that intravenous infusion of 30 and 70 U/kg of thrombin leads to the development of a short-term hypercoagulation phase which is replaced by long-term hypocoagulation and marked stimulation of fibrinolysis. An electrocardiogram provides evidence that after the infusion of 70 U/kg of thrombin acute ischemic disorders of coronary circulation develop in the dogs and remain for 3 days. The authors contend that the appearance of high doses of thrombin in the vascular channel is not a physiological reaction.

[Effect of histamine on blood and lymph coagulability].

It has been established in dog experiments that histamine (0.05 mg/kg) induces a considerable rise in blood coagulation, an increase in prothrombin consumption and plasma tolerance to heparin a diminution of fibrinase content and enhancement of fibrinolysis. Lymph coagulation and fibrinolytic activity remain unchanged.

[Comparative characteristics of blood and lymph clotting and fibrinolytic activity].

In dogs, the lymph coagulation occurs much more slowly than that of the blood. This is due to low concentration of the coagulation factors (I, II, V, VII, VIII, X, XI+XII) and to an increased level of heparin in the lymph. The fibrinolytic activity of lymph is somewhat higher than that of the blood which may be due to the low concentration of antiplasmines.

[Effect of intravenous infusions of thrombin and heterogenous blood on lymph coagulability].

In dogs, i.v. administration of thrombin leads to hypocoagulation, consumption of fibrinogen, increasing fibrinolysis, and to a slight raise of antithrombin.

[Effect of different doses of strychnine on blood coagulation and lymph].

Tests conducted with dogs ascertained that strychnine used in a dose producing convulsions brings on an intensified coagulation of the blood and lymph along with a higher fibrinolytic activity. This reaction is largely due to the ejection of thromboplastic and fibrinolytic agents from the active muscles.