Temporal Summation but Not Expectations of Pain Relief Predict Response to Acupuncture Treatment in Fibromyalgia.

Fibromyalgia (FM) is a common chronic pain condition for which acupuncture treatment is increasingly utilized. However, there is no universally accepted measure to predict whether a specific patient will benefit from acupuncture. This is a single-center, single-blind, sham-controlled, randomized, noncrossover, longitudinal trial of 76 subjects with FM, assigned to either electroacupuncture (EA) or a placebo control, mock laser (ML) acupuncture.

Methohexital - Induced lateralized periodic discharges during Wada test.

Objective: The Wada test is used to evaluate language lateralization and memory performance after inactivation of an isolated cerebral hemisphere. Methohexital a short-acting barbiturate has a history of use to induce interictal discharges during intraoperative corticography. We report a new finding of activation of lateralized periodic discharges (LPDs) after Methohexital injection.

Greater Somatosensory Afference With Acupuncture Increases Primary Somatosensory Connectivity and Alleviates Fibromyalgia Pain via Insular γ-Aminobutyric Acid: A Randomized Neuroimaging Trial.

Objective: Acupuncture is a complex multicomponent treatment that has shown promise in the treatment of fibromyalgia (FM). However, clinical trials have shown mixed results, possibly due to heterogeneous methodology and lack of understanding of the underlying mechanism of action. The present study was undertaken to understand the specific contribution of somatosensory afference to improvements in clinical pain, and the specific brain circuits involved.

Diffusion tensor imaging predicts cognitive function change following partial brain radiotherapy for low-grade and benign tumors.

Purpose/objectives: Radiation injury to parahippocampal cingulum white matter is associated with cognitive decline. Diffusion tensor imaging (DTI) detects micropathologic changes in white matter. Increased radial diffusion (RD) and decreased axial diffusion (AD) correspond to demyelination and axonal degeneration/gliosis respectively.

One center's experience with complications during the Wada test.

This study aimed to define the number and type of complications associated with the Wada test at an academic medical center for comparison to previous reports. We performed a retrospective review of medical records for patients who underwent the Wada test at the University of Michigan between April 1991 and June 2013. Information was collected regarding the angiography procedure and the immediate postoperative period to assess for both clinical and angiographic complications.

Diffusion tensor imaging of normal-appearing white matter as biomarker for radiation-induced late delayed cognitive decline.

Purpose: To determine whether early assessment of cerebral white matter degradation can predict late delayed cognitive decline after radiotherapy (RT).

Methods And Materials: Ten patients undergoing conformal fractionated brain RT participated in a prospective diffusion tensor magnetic resonance imaging study. Magnetic resonance imaging studies were acquired before RT, at 3 and 6 weeks during RT, and 10, 30, and 78 weeks after starting RT.

Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for prediction of radiation-induced neurocognitive dysfunction.

Purpose: To determine whether early assessment of cerebral microvessel injury can predict late neurocognitive dysfunction after brain radiation therapy (RT).

Experimental Design: Ten patients who underwent partial brain RT participated in a prospective dynamic contrast-enhanced magnetic resonance imaging (MRI) study. Dynamic contrast-enhanced MRI was acquired prior to, at weeks 3 and 6 during, and 1 and 6 months after RT.

Neuronal plasticity: historical roots and evolution of meaning.

In this paper, we outline some important milestones in the history of the term "plasticity" in reference to the nervous system. Credit is given to William James for first adopting the term to denote changes in nervous paths associated with the establishment of habits; to Eugenio Tanzi for first identifying the articulations between neurons, not yet called synapses, as possible sites of neural plasticity; to Ernesto Lugaro for first linking neural plasticity with synaptic plasticity; and to Cajal for complementing Tanzi's hypothesis with his own hypothesis of plasticity as the result of the formation of new connections between cortical neurons. Cajal's early use of the word plasticity is demonstrated, and his subsequent avoidance of the term is tentatively accounted for by the fact that other authors extended it to mean neuronal reactions partly pathological and no doubt quite different from those putatively associated with normal learning.

Behavioural and electrophysiological analysis of strabismus in cats: modern context.

We studied the effects of paralytic strabismus on visual behaviour and binocularity of cortical visual mechanisms by immobilization of one eye in adult cats. Visual discrimination abilities of the immobilized eye were significantly diminished despite extensive training with one or both eyes. The deficits are not caused by the immobilization itself but appear to reflect an adaptive mechanism to deal with double vision.

The hidden structure of neuropsychology: text mining of the journal Cortex: 1991--2001.

Background: The stated mission of Cortex is "the study of the inter-relations of the nervous system and behavior, particularly as these are reflected in the effects of brain lesions on cognitive functions." The purpose of this paper is to explore the relationship between the stated mission and the executed mission as reflected by the characteristics of papers published in Cortex. In addition, we examine whether the results and conclusions of an analysis of this kind are affected by the level of description of the published papers.

Sodium methohexital (brevital) as an anesthetic in the Wada test.

Purposes: We report our experience with sodium methohexital (Brevital) as an anesthetic used in the Wada test for language and memory in 86 epilepsy surgery patients (173 procedures).

Methods: The methods are compared with those of the more commonly used anesthetic sodium amobarbital (Amytal).

Results: Despite differences between the methohexital and amobarbital test protocols, the behavioral and neurologic effects of the two anesthetics are similar.

Left and right hemisphere contributions to physiognomic and verbal discrimination.

The relative contributions of the right- and left-temporal lobes in rapid recognition of faces and letters were studied in patients with anterior right- or left-temporal lobe excisions and a matched control group. On the basis of findings in patients with unilateral and bilateral brain damage, it was hypothesized that left hemisphere damage would not change the reaction time of letters analyzed by the right hemisphere and that right hemisphere damage would not change the reaction time of faces analyzed by the left hemisphere. The hypothesis was supported for letters but not for faces.

Presurgery expectations, postsurgery satisfaction, and psychosocial adjustment after epilepsy surgery.

Purpose: The medical benefits of epilepsy surgery are well documented, but the psychosocial consequences of surgery have received less attention. This is especially true of the roles of expectations and satisfaction in postsurgery functioning. The present study was designed to examine the relationships between expectation, satisfaction with surgery, and psychosocial functioning in patients and their significant others before and after epilepsy surgery.

Electrocerebral recovery during the intracarotid amobarbital procedure: influence of interval between injections.

Purpose And Methods: During the intracarotid amobarbital procedure (IAP) at the University of Michigan, continuous scalp EEG monitoring guides the timing for presentation of memory items and postinjection testing. Most of our patients have undergone bilateral injections. The interval between injections varied from 22 to 60 min, depending on the test and recovery time, as well as the time to catheterize the second side.

Absence of normal activation of the left anterior fusiform gyrus during naming in left temporal lobe epilepsy.

Patients with left temporal lobe epilepsy (TLE) often have impaired naming. We studied 13 patients with left TLE and 10 healthy control subjects with [(15)O]H2O PET during visual confrontation naming. Statistical mapping detected multiple regions of significant cerebral blood flow increases within individuals.

How gender affects psychological adjustment one year after coronary artery bypass graft surgery.

This research investigated gender differences in psychological adjustment among patients (112 males, 39 females) one year after coronary artery bypass graft surgery (CABG). Information regarding post-CABG depression, non-cardiac chronic conditions, and socioeconomic variables were obtained from a survey. Additional cardiac, surgical, and demographic data were retrieved from a hospital computer database.

Tactile rod bisection: hemispheric activation and sex differences.

Blindfolded subjects estimated with either hand the center of rods positioned in either left or right hemispace. In one condition, they also performed a concurrent verbal task. Bias and variability of bisection settings were the dependent variables.

Effects of stimulus source and intensity on covert orientation to auditory stimuli.

Normal subjects showed costs and benefits of informative auditory spatial cues with auditory targets in RT tasks when stimulus intensity was low, or when the stimuli were presented monaurally through headphones. These findings imply that attention to auditory stimuli, like attention to visual or tactile stimuli, can be shifted spatially in detection tasks, and that covert orienting to auditory stimuli occurs in conditions favoring the intention to orient the head to a sound source. According to this view, orienting of attention to auditory stimuli, as well as to visual and tactile stimuli, is linked functionally to mechanisms controlling overt orienting movements that increase stimulus identification.

Advance directives: making them more available to hospitals patients.

This article details methods developed to facilitate patients' understanding and execution of an advance directive (e.g., living will, treatment preferences, and durable power of attorney for healthcare).

The psychologist's role in assessing and facilitating patients' knowledge of advance directives in medical settings: A preliminary investigation.

In a time of budgetary shortfalls in the medical industry, an aging population, and an increased emphasis on health care choices, psychologists are being called upon to administer advance medical directive programs to patients. This study reports preliminary findings from a program to assess and facilitate patients' knowledge of advance directives (ADs) by the Psychology Service at the Ann Arbor VA Medical Center. The participant pool included 243 male veteran patients admitted to medical and surgical wards at the hospital.