Site-differential gastrointestinal absorption of benazepril hydrochloride in healthy volunteers.

The absorption of benazepril-HCl (BZPH), an orally active angiotensin-converting enzyme (ACE) inhibitor, in various regions of the gastrointestinal (GI) tract was investigated using an intestinal intubation technique. Thirteen subjects completed this single-dose, three-phase sequential crossover study. The drug (20 mg) was administered either as a 4-hr colonic infusion (COLON) or as a small intestinal infusion (SI) in the first two phases and as an oral bolus solution (ORAL) in the third phase, with a 2-week washout between each treatment.

A study of pharmacokinetic interaction between buspirone and alprazolam at steady state.

The steady-state pharmacokinetic interaction between buspirone and alprazolam was evaluated in a parallel study with two groups of 12 male volunteers each. On days 1 to 7, group I subjects received a 1-mg alprazolam tablet every 8 hours (q8h) (TRT 1) and group II subjects received 2 x 5-mg buspirone tablets q8h (TRT 2). On days 8 through 14, all subjects received a combination of 1-mg alprazolam and 2 x 5-mg buspirone tablets q8h (TRT 3).

Familial CNS tumors.

A family with central nervous system tumors in five individuals in two generations is reported. Of five sisters, two had an isolated meningioma and one an ependymoma. Amongst the four children of those affected there was a son with two cerebral meningiomas and a daughter with a spinal meningioma.

Animal and plant mitochondria contain specific thioredoxins.

Thioredoxins have been purified from pig heart and potato tuber mitochondria which differ in chromatographic behaviour, enzyme activating capacity, and slightly higher molecular mass (Mr = 12,500) from the major thioredoxin(s) present in mitochondria-free fractions of the same tissue. Both mt-thioredoxins can serve as hydrogen donor for E. coli ribonucleotide reductase but only the plant protein activates spinach chloroplast NADP malate dehydrogenase in vitro.

Renal tolerance of fleroxacin in healthy volunteers.

In order to evaluate kidney tolerance of fleroxacin, a new fluoroquinolone, we performed a volunteer study with 16 healthy males, 20-27 years old. On three consecutive days 800 mg of fleroxacin was administered orally. Alanine-aminopeptidase and distal- and pan-tubular antigens were determined in 24 h urine collections with specific monoclonal antibodies.

[Diskography--myelography].

One hundred patients were submitted to a prospective, comparative study of metrizamide myelography and discography. In the 32 patients with cervical myelopathy discography yielded no additional information and was thus abandoned. The 68 patients with radiculopathy disease the following results were obtained: In view of the agreement between clinical and myelographic monosegmental findings, discography was considered unnecessary.

Sustained effect of zinc-protamin-glucagon in hyperlipidaemic patients.

Is is well known from laboratory investigations and acute intervention studies that glucagon is involved in lipid metabolism. The present study was undertaken in order to evaluate a possible sustained effect of zinc-protamin-glucagon in moderately hyperlipidaemic patients. 4 patients were investigated after an acute bolus dose of glucagon 5 mg intravenously and 16 patients were given zinc-protamin-glucagon 5 mg subcutaneously, b.

Cervical disk syndromes: value of metrizamide myelography and diskography.

This paper reports on the respective diagnostic values of myelography with water-soluble contrast media and diskography in a study of 100 patients examined between 1979 and 1981 and operated on because of cervical disk disease. The results of the study led to a change of the diagnostic procedures formerly applied in radicular syndromes (i.e.

Vaginal Candida albicans treated with three different concentrations of natamycin (Pimafucin) for 6 days.

In 88 patients with vaginal Candida albicans a treatment was performed with natamycin vaginal cream for 6 days in daily doses of 5 ml at concentrations 25 mg natamycin/5 ml (Pim-25), 50 mg natamycin/5 ml (Pim-50), and 100 mg natamycin/5 ml (Pim-100). The cure rates, assessed according to negative cultures of swabs 4-7 days after discontinuation of the treatment, were 89.3%, 85.

Treatment of vaginal candidosis with natamycin and effect of treating the partner at the same time.

Thirty-three patients with vaginal candidosis were treated with natamycin vaginal tablets for 10 days and their partners were treated double-blind with natamycin cream/placebo cream. Follow-up examinations were carried out one week after the treatment was discontinued and again about one month later. The cure rate in patients having actively treated partners was 94%, not differing significantly from the cure rate of 88% in patients whose partners had been treated with placebo.

Calcinosis in Generalised Morphea.

A rare case of generalised morphea with extensive calcification in a female patient is reported. The literature on the same is briefly reviewed.

Transient ECG changes during acute attacks of pancreatitis.

Information on the prevalence of ECG abnormalities in patients with acute pancreatitis together with pertinent simultaneous laboratory data have been missing. This prospective study was undertaken in order to clarify these points. 54 patients with 72 acute attacks of pancreatitis were examined.