Warfarin-related nephropathy: possible role for the warfarin pharmacogenetic profile.

Warfarin-related nephropathy (WRN) is a renal complication of warfarin treatment associated with over-anticoagulation. We describe a case of a 73-year-old man affected by chronic kidney disease, essential hypertension and atrial fibrillation treated with warfarin. The patient presented a rapid course of kidney failure after many episodes of over-anticoagulation, and renal biopsy demonstrated WRN.

Malignant mesothelioma of the pleura in nonagenarian patients.

Aims And Background: Malignant mesothelioma developing at very old ages is a rare event. The reasons for such late development were investigated.

Methods: A series of 811 malignant mesothelioma of the pleura, diagnosed at the Trieste and Monfalcone Hospitals, in northeastern Italy, in the period 1968-2008 were reviewed.

[Pancreatic resection and hypothermic peritoneal irrigation in the treatment of patients with necrotizing pancreatitis].

Mortality of non-operated patients suffering from necrotizing pancreatitis is very high, while at those operated is considerably less but not satisfactory. Because of in 1976 we have managed our own modified treatment which includes surgical removal of all necrotic tissue followed by the hypothermic continuous peritoneal lavage-drainage procedure for evacuation of residual devitalized dead tissue and elimination biologically active substances. Using this curative method, we succeeded to reduce mortality rate to 26 percent.

[Endoscopic & histopathologic features of esophageal ulcers. Considerations in 13 cases].

Chronic, severe reflux esophagitis can be complicated with an esophageal ulcer (EU), whose histomorphological characteristics change sensibly. Between 1983 and 1989, 18 EU were endoscopically identified in 13 (6%) out of 217 patients with chronic gastroesophageal reflux (GER). 2 groups were defined: EU and esophagitis, without columnar-lined esophagus and EU with localized columnar metaplasia or Barrett's esophagus.

[Computed tomography and magnetic resonance in the preoperative staging of the spread of rectal cancer. A correlation with the anatomicopathological aspects].

In order to assess the accuracy of CT and MRI in evaluating the local extent of rectal carcinoma, 22 patients with a rectoscopic diagnosis of rectal cancer were examined before surgery with both techniques. Tumor extent into the perirectal fat, involvement of surrounding structures and local adenopathy were evaluated on both CT and MR images. These findings were compared with the micro- and macrohistologic findings obtained from the surgical specimens.

Carcinosarcoma and separate neuroendocrine malignant tumor of a malignancy promoter, the gastric stump.

We report a case of carcinosarcoma and separate neuroendocrine malignant tumor of the gastric stump. The case is interesting because of its unique pathological features and it confirms the role of the gastric stump as a very important "malignancy promoter".

The schwannoma: an uncommon type of cystic lesion of the pancreas.

Schwannomas of the pancreas are rare and their number is lower than is usually reported in the literature since some were probably neurofibromas. We report a further case characterized by cystic feature, clinically mimicking a pancreatic pseudocyst. Cystic lesions of the pancreas also comprise the schwannomas, both benign or malignant, as has been previously reported and is stressed by the present case.