Publications by authors named "Bucci Tommaso"
Background: Few data are available about the impact of oral anticoagulants (OAC) in patients with Atrial Fibrillation (AF) and clinical complexity (CC).
Methods: We conducted a retrospective study utilising data from the TriNetX network. Based on ICD-10-CM codes entered between 2020 and 2022, AF patients aged ≥75 years on long-term OAC with CC were categorised into two groups based on OAC use in the year before entering the study (maintained vs discontinued).
Background: In patients with atrial fibrillation (AF), the impact of peripheral artery disease (PAD) on oral anticoagulant (OAC) therapy use and the risk of outcomes remains unclear.
Objective: To analyse the epidemiology of PAD in a large cohort of European and Asian AF patients, and the impact on treatment patterns and risks of adverse outcomes.
Methods: We analysed AF patients from two large prospective observational registries.
Background: Few data are available on the clinical course of patients with supraventricular tachycardia (SVT).
Objective: The purpose of this study was to assess the 1-year risk of adverse events in patients with SVT.
Methods: This was a retrospective observational study conducted within TriNetX.
Background: Macrolide maintenance therapy (MMT) has demonstrated notable efficacy in reducing exacerbation in patients with bronchiectasis, which is a major risk factor for cardiovascular events. However, a comprehensive assessment of the cardiovascular benefits and safety profile of MMT in this population is lacking.
Methods: This territory-wide cohort study analyzed patients diagnosed with bronchiectasis in Hong Kong between 2001 and 2018.
Introduction: The risk of dementia in patients with stroke-heart syndrome (SHS) remains unexplored.
Patients And Methods: Retrospective analysis using the TriNetX network, including patients with ischaemic stroke from 2010 to 2020. These patients were categorised into two groups: those with SHS (heart failure, myocardial infarction, ventricular fibrillation, or Takotsubo cardiomyopathy within 30 days post-stroke) and those without SHS.
Background: Primary antiphospholipid syndrome (PAPS) has been associated with an increase in clinical events associated with atherosclerotic vascular disease. Intima media thickness (IMT) of carotid arteries is a surrogate marker of atherosclerotic vascular disease.
Objectives: To conduct a systematic review and meta-analysis of studies evaluating IMT and their clinical correlates in PAPS.
Article Synopsis
- Metformin, the most commonly prescribed medication for type 2 diabetes, is associated with gastrointestinal (GI) adverse events that can limit its use in patients.
- A systematic review and meta-analysis of 21 studies aimed to determine the prevalence of these GI adverse events, finding that diarrhea (6.9%) and bloating (6.2%) were the most common issues.
- Extended release (XR) metformin was shown to have lower incidences of GI issues, suggesting it's better tolerated than the immediate release (IR) formulation.
Introduction: Statins reduce recurrent stroke and cardiovascular events in patients with non-cardioembolic stroke. The benefits of statins in patients with AF and recent IS remain unclear. We aimed to investigate the benefits of statins in patients with AF and recent IS.
View Article and Find Full Text PDFBackground: There is a growing burden of non-obese people with diabetes mellitus (DM). However, their cardiovascular risk (CV), especially in the presence of cardiovascular-kidney-metabolic (CKM) comorbidities is poorly characterised. The aim of this study was to analyse the risk of major CV adverse events in people with DM according to the presence of obesity and comorbidities (hypertension, chronic kidney disease, and dyslipidaemia).
View Article and Find Full Text PDFBackground: Data on the association between atrial fibrillation (AF) and venous thromboembolism (VTE) are controversial.
Objectives: The purpose of this study was to investigate the risk of VTE in patients with AF according to the time from AF diagnosis.
Methods: Systematic review of MEDLINE (PubMed), Embase, Cumulative Index to Nursing and Allied Health Literature (EBSCO host), Cochrane Central Register of Controlled Trials (2020) in the Cochrane Library, and World Health Organization Global Index Medicus databases and meta-analysis of observational studies.
Background: . The long-term impact of gestational complications on cardiovascular outcomes in women remains a subject of debate.
Aim: To assess the 5-year risk of cardiovascular events and all-cause mortality in women with gestational diabetes and hypertension.
Anthracyclines are associated with enhanced oxidative stress responsible for adverse events in patients with breast cancer. However, no study has investigated the potential anti-inflammatory role of statins in counteracting anthracycline toxicity. In this retrospective study utilizing a federated health network (TriNetX), patients with breast cancer (ICD code C50) treated with anthracyclines were categorized into two groups: statin users (for at least 6 months); and statin non-users.
View Article and Find Full Text PDFBackground: The clinical impact of nonalcoholic fatty liver disease (NAFLD) in patients with atrial fibrillation (AF) is still controversial.
Aim: To evaluate the 1-year risk of all-cause death, thromboembolic events, and bleeding in patients with AF-NAFLD.
Methods: Retrospective study with a health research network (TriNetX).
Article Synopsis
- Cardiac resynchronization therapy (CRT) emerged in the 2000s as an important treatment for heart failure patients with poor ejection fraction and wide QRS, but around one-third of patients do not respond well to it.
- The review emphasizes that determining whether a patient is a CRT nonresponder is complex and should consider multiple factors rather than a single criterion.
- New pacing techniques like His-bundle and left bundle branch area pacing offer promising alternatives to CRT, but more comprehensive studies are necessary to validate their effectiveness in treating heart failure with electromechanical dyssynchrony.
Low-dose azithromycin prophylaxis is associated with improved outcomes in people suffering frequent exacerbations of chronic obstructive pulmonary disease (COPD), but the use of macrolides in patients with cardiovascular disease has been debated. To investigate the risk of adverse events after COPD exacerbations in patients with atrial fibrillation (AF) treated with azithromycin prophylaxis. Retrospective cohort study within the TriNetX Platform, including AF patients with COPD exacerbations.
View Article and Find Full Text PDFBackground: Insulin resistance (IR) is the cornerstone of Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD), pathophysiologically being the key link between MASLD, metabolic disorders, and cardiovascular (CV) diseases. There are no prospective studies comparing the predictive values of different markers of insulin resistance (IR) in identifying the presence of MASLD and the associated risk of cardiovascular events (CVEs).
Methods: Post hoc analysis of the prospective Plinio Study, involving dysmetabolic patients evaluated for the presence of MASLD.
Background: The aim of this study was to evaluate the impact of educational status (ES) on the clinical course of Asian patients with atrial fibrillation (AF).
Methods: We used data from the prospective APHRS-AF Registry. ES was classified as follows: low (primary school), medium (secondary), and high (University).
Valproate is the most effective treatment for idiopathic generalized epilepsy. Current guidance precludes its use in females of childbearing potential, unless other treatments are ineffective or not tolerated, because of high teratogenicity. This risk was recently extended to males.
View Article and Find Full Text PDF: To review the evidence on the effectiveness and safety of low-dose-rivaroxaban 2.5 mg twice daily (LDR) in patients with coronary artery disease (CAD) and/or peripheral artery disease (PAD) taking antiplatelets. : We performed a systematic review and meta-analysis of randomized controlled trials (RCTs).
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to assess the adverse health events in Asian patients with atrial fibrillation (AF) and diabetes mellitus (DM) through a large cohort analysis from the APHRS AF Registry.
- It found that patients with DM had significantly higher risks of all-cause death, cardiovascular death, and major bleeding compared to those without DM after one year of follow-up.
- The results suggest a need for improved management strategies for these high-risk patients, particularly since the impact of DM on health outcomes was more pronounced in younger patients.
Article Synopsis
- * The study found that patients with COPD had significantly higher rates of all-cause death, cardiovascular death, and heart failure compared to those without COPD, with COPD linked to a more than threefold increase in risk for these outcomes.
- * Additionally, the use of beta blockers in COPD patients with AF was associated with lower mortality rates, suggesting potential benefits for treatment strategies in this demographic.
Background: Growing evidence showing that systemic autoimmune diseases (SADs) are associated with a high risk of atrial fibrillation (AF). However, the impact of SAD on the clinical course of AF patients is largely unknown.
Methods: Retrospective cohort study within a federated healthcare network (TriNetX).
Objective: A diagnosis of epilepsy has been associated with adverse cardiovascular events (CEs), but the extent to which antiseizure medications (ASMs) may contribute to this is not well understood. The aim of this study was to compare the risk of adverse CEs associated with ASM in patients with epilepsy (PWE).
Methods: A retrospective case-control cohort study was conducted using TriNetX, a global health federated network of anonymized patient records.
Patients with heart failure with reduced ejection fraction (HFrEF) and diabetes mellitus (DM) have an increased risk of adverse events, including thromboembolism. In this analysis, we aimed to explore the association between DM and HFrEF using data from the "Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction" (WARCEF) trial. We analyzed factors associated with DM using multiple logistic regression models and evaluated the effect of DM on long-term prognosis, through adjusted Cox regressions.
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