[Prevalence of peripheral arterial disease and correlative risk factors among natural population in China].

Objective: To investigate the prevalence of peripheral arterial disease (PAD) and correlative risk factors among natural population in China.

Methods: Ankle brachial index (ABI) was measured by trained doctors and related data were collected in residents from Beijing, Shanghai, Changsha, Guangdong, Neimenggu, and Xinjiang selected through cluster multistage and random sampling method. PAD was defined as an ABI < or = 0.

Chronic kidney disease, all-cause mortality and cardiovascular mortality among Chinese patients with established cardiovascular disease.

Aim: This study was conducted to investigate the role of chronic kidney disease (CKD) in 1-year all cause mortality and cardiovascular mortality among Chinese patients who were at least 50 years old and had a history of coronary artery disease (CAD), stroke, or peripheral vascular disease (PAD), or with two or more cardiovascular risks.

Methods: Of 3,732 hospitalized patients enrolled, 3,423 patients (91.7%) with complete data were eligible for 1-year follow-up.

Prevalence of and risk factors for peripheral arterial disease among Chinese hypertensive patients with and without known cardiovascular disease.

Introduction: Peripheral arterial disease (PAD) is an important manifestation of systemic atherosclerosis.The present study was to estimate the prevalence of and risk factors for PAD in Chinese hypertensive patients with and without known cardiovascular disease (CVD) which consisted of coronary heart disease, angina, stroke, and transient ischaemic attack.

Material And Methods: A cross-sectional study consisting of 5,186 hypertensive patients was conducted from July to November 2004 in Beijing and Shanghai, China.

[The relationship of ankle brachial index to all-cause and cardiovascular disease mortality in Chinese male patients with hypertension].

Objective: To evaluate the risk factors for peripheral arterial disease (PAD) and the relationship of low ankle brachial index (ABI) to all-cause and cardiovascular disease (CVD) mortality in Chinese male patients with hypertension.

Methods: The data of 1606 male participants with hypertension from the eight hospitals in Beijing and Shanghai were analyzed. ABI was ascertained at baseline by measuring the systolic pressures on bilateral brachial and tibial arteries.

[Relationship between low ankle-brachial index and mortality of men with several atherosclerotic risk factors: a cohort study of 1941 cases].

Objective: To study the relationship between ankle-brachial index (ABI) and all cause mortality and cardiovascular disease mortality in men with several atherosclerotic risk factors.

Methods: 1941 male patients with no less than two atherosclerotic risk factors, aged 67 (36 approximately 96), from 20 hospitals in Shanghai and Beijing, underwent examination of ABI and were followed up for 13.6 +/- 1.

Risk factors of peripheral arterial disease and relationship between low ankle - brachial index and mortality from all-cause and cardiovascular disease in Chinese patients with type 2 diabetes.

Background: The aim of the present study was to evaluate the risk factors for peripheral arterial disease and the relationship between the ankle - brachial index (ABI) and mortality from all-cause and cardiovascular disease (CVD) in Chinese patients with type 2 diabetes mellitus (DM).

Methods And Results: ABI was identified at baseline by measuring systolic pressure in the bilateral brachial and tibial arteries. Mortality surveillance was completed from November 2004 to January 2006.

Evaluation of medical treatment for peripheral arterial disease in Chinese high-risk patients.

Background: Peripheral arterial disease (PAD) is an important manifestation of systemic atherosclerosis and is associated with elevated cardiovascular morbidity and mortality. The aim of the present study was to evaluate the use of antiplatelet agents, statins and angiotensin-converting enzyme inhibitors (ACEI) in Chinese high-risk cardiovascular (CV) patients with PAD, with an emphasis on the need for aggressive medical management of all atherosclerotic manifestations.

Methods And Results: Medical records from 5,263 Chinese patients at high risk of CV were evaluated for the use of antiplatelet agents, statins and ACEI in patients with and without PAD.

[Study on the independent association of uric acid levels with peripheral arterial disease in Chinese patients with coronary heart disease].

Objective: To evaluate the relationship between uric acid (UA) and peripheral arterial disease (PAD) in Chinese patients with coronary heart disease (CHD).

Methods: UA levels and PAD were evaluated in 3251 Chinese hospitalized patients with CHD (age > or = 50 years). PAD was diagnosed when the ankle-brachial index was < 0.

Ankle brachial index as a marker of atherosclerosis in Chinese patients with high cardiovascular risk.

To obtain reliable data on the epidemiology, co-morbidities and risk factor profile of peripheral arterial disease (PAD), we evaluated the clinical significance of the ankle brachial index (ABI) as an indicator of PAD in Chinese patients at high cardiovascular (CV) risk. ABI was measured in 5,646 Chinese patients at high CV risk, and PAD was defined as an ABI<0.9 in either leg.

[Research of the relationship between smoking and peripheral arterial disease].

Objective: To investigate the relationship between smoking and peripheral arterial disease (PAD) by investigate the smoking status and measuring the (ABI).

Methods: A questionnaire survey was conducted among 3379 male patients hospitalized in the departments of cardiovascular internal medicine, nephrology, and endocrinology, aged 40-98, 2253 smokers and 1126 non-smokers, to understand their life styles, anamnesis, and smoking history. All patients underwent measurement of systolic blood pressures of the upper arm and ankle so as to calculate the ankle-brachial index (ABI).

A novel variable number of tandem repeat polymorphism of the renin gene and essential hypertension.

The aims of the present study were to find new genetic markers of essential hypertension (EH) and to investigate relationships between EH and polymorphisms of the renin gene. Using single strand conformation polymorphism, we discovered a new variable number of tandem repeat (VNTR) polymorphism in intron 7 that is 18 bp upstream from the boundary with exon 8. Nucleotide sequencing revealed that this VNTR polymorphism is a tandem repeat of the 4-nucleotide sequence TCTG.

Haplotype analysis of the human renin gene and essential hypertension.

The human renin gene is an attractive candidate for involvement in the underlying cause of essential hypertension (EH). Despite extensive examination, the relation between the renin gene and hypertension remains unclear. The aims of the present study were to discover new genetic markers of EH and to investigate the relations between polymorphisms of the renin gene and EH in the Japanese.

Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension.

Prostacyclin inhibits platelet aggregation, smooth muscle cell proliferation, and vasoconstriction. The prostacyclin synthase (PGIS) gene is a candidate gene for cardiovascular disease. The purpose of this study was to locate possible mutations in the PGIS gene related to hypertension and cerebral infarction.