Publications by authors named "Bu-Qing Fu"
Aneuploidy underlies brefeldin A-induced antifungal drug resistance in .
Front Cell Infect Microbiol
July 2024
Article Synopsis
- * It reveals that exposure to Brefeldin A (BFA), which induces endoplasmic reticulum stress, leads to the formation of aneuploidy, specifically disomy in certain chromosomes, affecting drug resistance patterns.
- * The study suggests that disomy of chromosome 1 causes cross-resistance to fluconazole and 5-flucytosine while increasing sensitivity to amphotericin B, indicating BFA could accelerate the emergence of drug resistance through genomic changes.