Publications by authors named "Bu-Fu Tang"
Article Synopsis
- * Radiotherapy (RT) not only damages DNA in cancer cells but also activates inflammatory signaling pathways that can reshape the immune environment, enhancing tumor control and potentially triggering immune responses in distant tumors (abscopal effects).
- * The review highlights the importance of understanding GI in cancer biology, suggesting that combining RT with immunotherapy may lead to better treatment strategies and improved patient outcomes by harnessing systemic anti-tumor immunity.
Cuproptosis, a new type of programmed cell death (PCD), is closely related to cellular tricarboxylic acid cycle and cellular respiration, while hypoxia can modulate PCD. However, their combined contribution to tumor subtyping remains unexplored. Here, we applied a multi-omics approach to classify TCGA_COADREAD based on cuproptosis and hypoxia.
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- - MELK (Maternal embryonic leucine zipper kinase) is part of the AMPK family and is found in high levels in various cancers, playing a critical role in tumor cell survival, growth, and movement.
- - It also influences the tumor microenvironment, which can help predict how tumors will respond to immunotherapy and affects immune cell functions that regulate tumor growth.
- - The development of small molecule inhibitors targeting MELK has shown promising anti-tumor effects in clinical trials, making MELK a potential therapeutic target for cancer treatment, though many of its mechanisms are still not fully understood.
Article Synopsis
- A novel MRI contrast agent, A54-CaP, made from calcium phosphate nanoparticles and modified with a liver cancer-targeting peptide, has been developed to improve the diagnosis of primary hepatocellular carcinoma (HCC).
- These nanoparticles encapsulate Gd-DTPA, a widely used contrast agent, and demonstrate significantly better sensitivity and higher accumulation in liver cells, as indicated by their superior longitudinal relaxivity.
- In vivo experiments show that A54-CaPNPs provide much better contrast enhancement and imaging duration for HCC detection compared to standard Gd-DTPA, highlighting their potential for non-invasive early diagnosis and timely surgical intervention.
In previous studies, miR-29s showed tumor suppressor properties against lung cancer, which improved the survival of patients upon the administration of chemotherapy via an unknown mechanism. Here, we investigated the regulatory effects of miR-29s on the cisplatin resistance of NSCLC cells. The expression of miR-29s was assessed in 130 clinical patients and in cisplatin-treated NSCLS cell lines.
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