Development and application of the physiologically-based toxicokinetic (PBTK) model for ochratoxin A (OTA) in rats and humans.

Ochratoxin A (OTA) is a common fungal toxin frequently detected in food and human plasma samples. Currently, the physiologically based toxicokinetic (PBTK) model plays an active role in dose translation and can improve and enhance the risk assessment of toxins. In this study, the PBTK model of OTA in rats and humans was established based on knowledge of OTA-specific absorption, distribution, metabolism, and excretion (ADME) in order to better explain the disposition of OTA in humans and the discrepancies with other species.

[Comparative Analysis on the Improvement of Air Quality in Beijing During APEC].

In order to evaluate the effects of the implementation of emission reduction measures and the revolution of air quality of Beijing during APEC, the evolution characteristics of air quality was analyzed based on the hourly monitored readings of Olympic Sports Center from 1 to 15 November 2014 released by Environmental Monitoring Station of China, and compared with that in 2013. The results showed that: (1) PM₂.₅ was the main pollutant in Beijing.

[Analysis on Regional Characteristics of Air Quality Index and Weather Situation in Beijing and Its Surrounding Cities During the APEC].

Analysis on the revolution and regional characteristics of air quality by hourly monitored readings from 1 to 15 November 2014 released by Environmental Monitoring Station of China and research of the impacts of weather situation and meteorological elements released by China Meteorological Administration towards air quality of Beijing and its surrounding cities during the Asia-Pacific Economic Cooperation (APEC) indicated that: (1) The air quality was good because of the implementation of mitigation measures, while the Air Quality Index (AQI) increased along with the termination of mitigation measures. Thus it can be seen that mitigation measures made a great contribution to the improvement of air quality of Beijing and its surrounding cities. (2) Affected by thermal inversion layer, AQI of Beijing and its surrounding cities increased quickly during the initial of the implemental of reducing measures which proved that pollutants would accumulate in the context of unfavourable weather, hence the influence of weather situation towards air quality could not be ignored.