[Changes in cerebral blood flow during mastication in patients receiving prosthesis insertion for repairing maxillary defect].

Objective: To investigate the changes in cerebral blood flow in patients with maxillary defect treated with prosthesis insertion.

Methods: Thirty patients with maxillary defect receiving obturator prosthesis insertion were enrolled with another 30 subjects without dentition defect as the control. The cerebral blood flow rate was recorded before and at 5 and 10 min during mastication, and the results were analyzed statistically.

Myoepithelial carcinoma of the parotid gland with bilateral thyroid involvement: A case report and review of the literature.

A patient was admitted to hospital with enlarged lobes of the thyroid gland with bilateral cervical lymph node involvement, and surgical excision followed. Histological examination of this specimen revealed a lesion that showed myoepithelial cell differentiation. Primary thyroid and skin appendage tumors were excluded based on clinical examination, conventional histology and immunohistochemistry.

[Simulation of timber-harvesting area in Xiao Xing' anling Mountains under climate change].

By using the spatially explicit forest landscape model (LANDIS 6.0 PRO), the percentages of timber-harvesting area in Xiao Xing' anling Mountains under current harvesting scenario and under 11 harvesting scenarios with alternating harvesting intensities (alternating time was 10, 20 and 30 years, respectively) in 2000-2400 under climate change were simulated. Alternating harvesting intensity could increase the harvesting area.

[Effects of eco-protection policy on land use/cover in upper reaches of Minjiang River].

By using CLUE-S model, a scenario analysis was made on the land use/cover change in the upper reaches of Minjiang River from 2000 to 2020, based on the historic development trend and the regulations of policies "natural forest protection" and "grain for green". In 2000-2020, according to the historic development trend, the forestland area (landscape matrix) in the study region would have a continual decrease while the shrub land and grassland areas would be increased, and the landscape pattern would be more fragmental. The implementation of the policies "natural forest protection" and "grain for green" would effectively increase forestland area, being able to reverse the trend of landscape fragmentation and more optimize the landscape pattern.

[Effect zone of forest road on plant species diversity in Great Hing 'an Mountains].

Forest road has far-reaching effects on plant species diversity across varying scales, and the estimation of its effect distance and effect zone is a key issue to integrate the road effect and ecological processes in forest area. In this paper, ten transects, 2 m wide and extending 50 m from varying grade roads including main road, main line for wood transportation, and secondary line for wood transportation in Huzhong forest area of Great Hing' an Mountains were set. The plant composition was investigated in twenty-five 2 m x 2 m plots of each transect.

[Soil respiration of degraded Korean pine forest ecosystem in Changbai Mountains].

Taking the broad-leaved Korean pine forest area in Changbai Mountains, a typical eastern forest belt of Northeast China for global change as test object, and by using the approaches of trenching-plot and infrared gas exchange analyzer, this paper analyzed the soil respiration in a selected series of degraded Korean pine forest ecosystem, i.e., broad-leaved Korean pine forest (CK), poplar-birch forest (Y), hardwood forest (S), Mongolian oak forest (M), and bare land (L).

[Long-term effects of Dendrolimus superans Bulter disturbance on forest landscape in Huzhong Forest Bureau of Great xing' an Mountains: a simulation study].

A spatially explicit landscape model LANDIS was applied to simulate the long-term effects of Dendrolimus superans Bulter disturbance on the forest landscape in Huzhong Forest Bureau of Great Xing' an Mountains. The statistical software pakage APACK was used to calculate the distribution area of D. superans and representative tree species, the aggregation index reflecting the spatial pattern, and the average area of forest patchs.

HGF/c-Met pathway has a prominent role in mediating antiapoptotic signals through AKT in epithelial ovarian carcinoma.

The Met receptor tyrosine kinase and its ligand, hepatocyte growth factor (HGF), are overexpressed and/or activated in a variety of human malignancies. However, its role in epithelial ovarian carcinoma (EOC) has not been clearly elucidated. Therefore, we investigated the role of HGF/c-Met signaling pathway in a large series (156) of Saudi EOC patient samples, a panel of cell lines, and xenografts in a NUDE mouse model.

Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling.

The inhibitor of apoptosis protein (IAP) family member X-linked inhibitor of apoptosis protein (XIAP) is essential for cell survival in lymphoma. However, the role of XIAP overexpression in diffuse large B-cell lymphoma (DLBCL) is not fully elucidated. Therefore, we analysed the expression of XIAP protein and its clinicopathological correlation in a large cohort of DLBCLs by immunohistochemistry in a tissue micro-array format.

Inhibition of c-MET is a potential therapeutic strategy for treatment of diffuse large B-cell lymphoma.

Hepatocyte growth factor/c-MET has emerged as a potential therapeutic target for several cancers; however, its role in diffuse large B-cell lymphoma (DLBCL) has not been fully elucidated. In this study, we first investigated the role of c-Met in a large series of DLBCL tissues in a tissue microarray format. We then followed this with in vitro studies on DLBCL cell lines using either pharmacological inhibitors of c-Met or siRNA knockdown strategy.

Leptin receptor expression and its association with PI3K/AKT signaling pathway in diffuse large B-cell lymphoma.

We investigated the role of the leptin receptor (Ob-R) and its relationship with PI3K/AKT activation in diffuse large B-cell lymphoma (DLBCL) clinical samples followed by in vitro studies using a panel of CRC cell lines. Leptin exerts its physiological action through its receptor Ob-R. Overexpression of Ob-R has been implicated in the pathogenesis of a variety of malignancies; however, its role in DLBCL has not been investigated.

Inhibition of fatty acid synthase suppresses c-Met receptor kinase and induces apoptosis in diffuse large B-cell lymphoma.

Fatty acid synthase (FASN), the enzyme responsible for de novo synthesis of fatty acids, has emerged as a potential therapeutic target for several cancers; however, its role in diffuse large B-cell lymphoma (DLBCL) has not been fully elucidated. In this study, we investigated the role of FASN in a large series of DLBCL tissues in a tissue microarray (TMA) format followed by in vitro studies using DLBCL cell lines. FASN was found to be expressed in 62.

Genetic polymorphisms of MTHFR and aberrant promoter hypermethylation of the RASSF1A gene in bladder cancer risk in a Chinese population.

Epidemiological studies have shown that folate deficiency increases the risk of cancer by affecting DNA repair and methylation. Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. In this study, it was hypothesized that MTHFR (C677T and A1298C) polymorphisms would be associated with bladder cancer and also with hypermethylation of the promoter of the Ras association domain family 1A (RASSF1A) gene.

Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma.

The putative role of leptin and its receptor (Ob-R) in the pathogenesis of various primary human malignancies has been reported; however, their role in papillary thyroid cancer (PTC) has not yet been evaluated. We investigated the role of Ob-R in a large tissue microarray cohort of PTC followed by in vitro studies using a panel of PTC cell lines. Ob-R overexpression was seen in 80% PTCs and was significantly associated with poor disease-free survival (P=0.

Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer.

Background: Recent epidemiological studies have suggested that obesity is associated with ovarian cancer. Obesity hormone leptin and its receptor (Ob-R) contribute to tumor development by enhancing cell growth and survival. This study was design to investigate the prevalence of leptin and Ob-R in Middle Eastern epithelial ovarian cancer (EOC) and to analyze the role of leptin and the mechanisms under its action in EOC tissue sample and cell lines.

Frequent PIK3CA gene amplification and its clinical significance in colorectal cancer.

Using a DNA microarray approach to screen for gene copy number changes in 20 colorectal (CR) carcinoma samples and filtering for high-level DNA copy number changes, we detected an amplicon at 3q26 containing the PIK3CA gene. Fluorescence in situ hybridization was employed for evaluation of PIK3CA amplification on a progression CR tissue microarray containing 448 CR carcinomas, normal mucosa, and adenomas with follow-up information. PIK3CA amplification (ratio PIK3CA/centromere 3 > or = 2.

Blending of the eyelid-cheek junction and removal of protruding fat: an intraoral approach to blepharoplasty of the lower eyelid.

Blepharoplasty is one of the most common aesthetic procedures done today. The protruding fat and lid-cheek junction are the most conspicuous signs of aging that need attention. During zygomatic reduction by an intraoral approach we found occasionally that the orbital fat can be exposed through the perforated periosteum at the inferior obital rim.

[Investigation and management of wound on head and neck from the disaster area in Wenchuan earthquake].

Objective: To investigate and analyze the wounded's state of ear, nose, throat, neck and head injury in Wenchuan earthquake.

Methods: The 206 wounded cases, who was treated in No. 452 Hospital of People's Liberation Army, were investigated specially with emphasis on injury cause, severity and treatment.

Synergistic effect of methyltetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphism as risk modifiers of pediatric acute lymphoblastic leukemia.

Background And Purpose: ALL is the most common pediatric cancer. The causes of the majority of pediatric acute leukemia are unknown and are likely to involve an interaction between genetic and environmental factors. Therefore, unfavourable gene-environmental interactions might be involved in the genesis of ALL.

[Modeling of forest landscape change in Xiaoxinganling mountains under different planting proportions of coniferous and broadleaved species].

With spatially explicit landscape model (LANDIS), the dynamic change of forest landscape in Youhao Forest Bureau in Xiaoxinganling Mountains from 2001-2201 under 5 planting proportions of coniferous and broadleaved species, i.e., 100% broadleaved species, 70% broadleaved and 30% coniferous species, 50% broadleaved and 50% coniferous species, 30% broadleaved and 70% coniferous species, and 100% coniferous species, was studied, taking the forest under natural regeneration after harvesting as the control.

Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers.

Context: Fatty acid synthase (FASN) is an enzyme that plays a critical role in de novo synthesis of fatty acids. FASN is overexpressed in variety of human cancers, but its role has not been elucidated in papillary thyroid carcinoma (PTC).

Objective: Our objective was to investigate the role of FASN and its relationship with phosphatidylinositol 3-kinase/AKT activation in a large series of PTC in a tissue microarray format followed by studies using PTC cell lines and Nude mice.

[Effects of different forest management alternatives on Sciurus vulgaris habitat].

A spatially explicit landscape model LANDIS was applied to simulate the forest landscape changes under four management alternatives (no cutting, clear cutting, selective cutting I and II) in Youhao Forestry Bureau located in Small Xing' an Mountain from 2000 to 2200. The outcomes from LANDIS were combined with a landscape-level habitat suitability index (HSI) model in a GIS environment to assess Sciurus vulgaris habitat quality. The results showed that the increase of suitable habitat area and the decrease of marginally suitable area were the fastest under no cutting scenario, and the slowest under clear cutting scenario.