Hydrocephalus in primary brainstem hemorrhage risk predictors and management.

This study explored the risk factors associated with hydrocephalus incidence and evaluated the effectiveness of surgical treatments in managing this condition. Patients with PBSH were retrospectively evaluated, identifying clinical and radiological characteristics. A multivariate logistic regression model was used for analyses.

The Impact of MSTN Gene Editing on Meat Quality and Metabolomics: A Comparative Study Among Three Breeds of MSTN-Edited and Non-Edited Cattle.

Myostatin (MSTN) serves as a negative regulatory factor for muscle development. A reduction in MSTN gene expression can enhance muscle mass and increase meat production. However, whether it will impact meat quality traits remains one of the major concerns in the cattle breeding industry.

Association between lymphocyte to high-density lipoprotein cholesterol ratio and insulin resistance and metabolic syndrome in US adults: results from NHANES 2007-2018.

Background: Insulin resistance (IR) and metabolic syndrome (MetS) are significant global health challenges that increase the risk of various chronic diseases. The lymphocyte-to-high-density lipoprotein cholesterol ratio (LHR) has emerged as a novel inflammatory metabolic marker. The present study focused on evaluating the association between the LHR and both IR and MetS.

Platinum-Nickel@High-Entropy Alloy Core@Satellite Nanowires as Efficient Bifunctional Electrocatalysts for PEMFC.

The optimized composition and precisely tailored structure configuration play critical roles in enhancing the catalytic reaction kinetics. Here we report a distinctive core@satellite strategy for designing the advanced platinum-nickel@platinum-nickel-copper-cobalt-indium high-entropy alloy nanowires (PtNi@HEA NWs) as efficient bifunctional catalysts in the proton exchange membrane fuel cell. Impressively, the PtNi@HEA NWs/C shows 19.

Compound 38, a novel potent and selective antagonist of adenosine A receptor, enhances arousal in mice.

Adenosine A receptor (AR) plays a pivotal role in the regulation of sleep-wake behaviors. We previously reported an AR selective antagonist compound 38 with an IC value of 29.0 nM.

Pharmacokinetics, efficacy, and safety of subcutaneous versus intravenous rituximab in previously untreated Chinese patients with CD20+ diffuse large B-cell lymphoma: a phase II randomized controlled trial.

Subcutaneous (SC) rituximab has demonstrated advantages over intravenous (IV) administration; however, insufficient data exist on its use with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in Chinese patients with diffuse large B-cell lymphoma (DLBCL). This multicenter, phase II, randomized, controlled study was conducted across China between February 2021 and October 2022. Fifty adult patients with previously untreated CD20-positive DLBCL were randomized to receive one cycle of IV rituximab and seven cycles of SC rituximab (R-CHOP;  = 26), or eight cycles of IV rituximab (R-CHOP;  = 24), combined with six or eight cycles of CHOP.

Evaluating the impact of weight and center of mass on comfort in head-mounted displays.

This study investigates the impact of the weight and centre of mass (COM) position of Head-Mounted Displays (HMDs) on the subjective evaluation of users during prolonged wearing tasks. This study involved 88 participants completing 1860 sets of experiments under three conditions: sitting still, turning the head, and moving, providing subjective evaluations of wearing HMDs. A static torque testing device was used to simulate neck torque under flexion states.

Effects of Far-Red Light and Ultraviolet Light-A on Growth, Photosynthesis, Transcriptome, and Metabolome of Mint ( Briq.).

To investigate the effects of different light qualities on the growth, photosynthesis, transcriptome, and metabolome of mint, three treatments were designed: (1) 7R3B (70% red light and 30% blue light, CK); (2) 7R3B+ far-red light (FR); (3) 7R3B+ ultraviolet light A (UVA). The results showed that supplemental FR significantly promoted the growth and photosynthesis of mint, as evidenced by the increase in plant height, plant width, biomass, effective quantum yield of PSII photochemistry (F'/F'), maximal quantum yield of PSII (F/F), and performance index (PI). UVA and CK exhibited minimal differences.

Efficient direct formic acid electrocatalysis enabled by rare earth-doped platinum-tellurium heterostructures.

The lack of high-efficiency platinum (Pt)-based nanomaterials remains a formidable and exigent challenge in achieving high formic acid oxidation reaction (FAOR) and membrane electrode assembly (MEA) catalysis for direct formic acid fuel cell (DFAFC) technology. Herein, we report 16 Pt-based heterophase nanotrepang with rare earth (RE)-doped face-centered cubic Pt (fcc-Pt) and trigonal Pt-tellurium (t-PtTe) configurations ((RE-Pt)-PtTe HPNT). Yttrium (Y) is identified as the optimal dopant, existing as single sites and clusters on the surface.

Malocclusion Associated With Temporomandibular Joint Anterior Disc Displacement and Condylar Resorption in Adolescents: A Cross-Sectional Study.

Background: Anterior disc displacement (ADD) is the most common type of temporomandibular joint (TMJ) internal derangement and may lead to condylar resorption (CR) during the adolescence period, but the specific malocclusion associated with ADD and CR remains unclear.

Objective: This study aimed to investigate the malocclusion associated with TMJ ADD and CR in adolescents.

Methods: This cross-sectional study included a clinical examination of adolescent patients aged 11-19 years.

Non-enhancing margin and pial invasion in MRI can predict IDH status in glioma patients.

Background: The presence of isocitrate dehydrogenase (IDH) mutations and 1p/19q codeletion significantly influences the diagnosis and prognosis of patients with lower-grade gliomas (LGGs). The ability to predict these molecular signatures preoperatively can inform surgical strategies. This study sought to establish an interpretable imaging feature set for predicting molecular signatures and overall survival in LGGs.

The ending is not the end: Lymph node metastasis in oral squamous cell carcinoma.

Lymph node metastasis is an important biological feature of oral squamous cell carcinoma, bearing poorly prognostic implications. However, the role of lymph node metastasis in cancer progression remains inconclusive. On the one hand, lymph nodes are pivotal sites for initiating specific immunity, which is crucial for maintaining antitumor immune response.

Black phosphorus nanomaterials mediate size-dependent acute lung injury by promoting macrophage polarization.

Black phosphorus nanomaterials (BPNM) exhibit excellent properties and potential applications in electronics, but workers may face inhalation exposure during BPNM production. In addition, there is a lack of biosafety assessments regarding respiratory exposure to BPNM of different sizes. In this study, we investigated the lung toxicity in mice exposed to 5, 50, 500 μg/kg of black phosphorus quantum dots (BPQDs) and black phosphorus nanosheet (BPNS) via single tracheal instillation.

CHD6 eviction of promoter nucleosomes maintains housekeeping transcriptional program in prostate cancer.

CHD6, a member of the chromodomain helicase DNA-binding protein family, has been implicated in various diseases and tumors. However, its precise binding model of CHD6 on regulatory functional genes remains poorly understood. In this study, we discovered sharp peaks of CHD6, as the first member of CHD family for housekeeping process, binding only to the promoter region of genes in the C4-2 cell line.

Haplotype analysis incorporating ancestral origins identified novel genetic loci associated with chicken body weight using an advanced intercross line.

Background: The genome-wide association study (GWAS) is a powerful method for mapping quantitative trait loci (QTL). However, standard GWAS can detect only QTL that segregate in the mapping population. Crossing populations with different characteristics increases genetic variability but F2 or back-crosses lack mapping resolution due to the limited number of recombination events.

Immunometabolism in head and neck squamous cell carcinoma: Hope and challenge.

Immunotherapy has improved the survival rate of patients with head and neck squamous cell carcinoma (HNSCC), but less than 20 % of them have a durable response to these treatments. Excessive local recurrence and lymph node metastasis ultimately lead to death, making the 5-year survival rate of HNSCC still not optimistic. Cell metabolism has become a key determinant of the viability and function of cancer cells and immune cells.

Recent developments in isothermal amplification technology for rapid detection of SARS-CoV-2.

Coronavirus disease 2019 (COVID-19), an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread globally, posing a significant threat to human health. Rapid and accurate detection of infectious disease pathogens is of crucial practical significance for early screening, timely intervention, and outbreak prevention. However, conventional diagnostic methods are increasingly unable to meet clinical demands.

Sex-Based Differences in the Associations Between Obesity- and Lipid-Related Indexes and Hyperuricemia Risk in Patients with Obesity.

Purpose: This study aimed to investigate the association of the triglyceride-glucose index (TyG) and its related parameters with the risk of hyperuricemia in patients with obesity of different sexes.

Patients And Methods: In this cross-sectional study, a total of 951 patients with obesity were included. They were divided into two groups based on their serum uric acid levels, and separate analyses were conducted for males and females.

Complications in Deep Circumflex Iliac Artery-Related Vascularized Free Iliac Flap.

Background: Since its first application in 1978, the vascularized free iliac flap (VFIF) has gradually become a mainstay for tissue defect reconstruction. However, the complications associated with harvesting the bone flap and its corresponding reconstruction surgery cannot be overlooked.

Methods: We conducted a narrative review through literature search to identify the types, incidence, influencing factors, measurement methods, and treatment approaches of complications related to DCIA-related VFIF.

A transcriptome data set for comparing skin, muscle and dorsal root ganglion between acute and chronic postsurgical pain rats.

Chronic postsurgical pain (CPSP), with a high prevalence and rising epidemic of opioids crisis, is typically derived from acute postoperative pain. Our knowledge on the forming of chronic pain mostly derives from mechanistic studies of pain processing in the brain and spinal cord circuits, yet most pharmacological interventions targeting CNS came to be unhelpful in preventing CPSP. Revealing the peripheral mechanisms behind the transition from acute to chronic pain after surgery could shine a light on the novel analgesic regimens.