[The effect of diabeton and metformin on the free-radical oxidation processes and the structural characteristics of the phospholipid composition of the erythrocyte membranes in non-insulin-dependent diabetes mellitus].

Newly detected noninsulin--dependent diabetes mellitus is shown to have changes in phospholipid structure of erythrocytic membranes: a fall in total phospholipids, sphingomyelin, phosphatidylcholine, phosphatidic acid, a trend to increasing lysophosphatidylcholine. The shifts go in parallel with lipid peroxidation activation. Carbohydrate metabolism compensation is not enough to eradicate the shifts.

[The effect of insulin on the lipid composition of the erythrocyte membranes of diabetics].

A study is presented of the dynamics of components of lipid spectrum of erythrocytic membrane in insulin-dependent type of diabetes mellitus against the background of traditional types of treatment (Porcine insulin and insulin-zinc-suspension) and use of monospike and monocomponent insulins. Insulins of high purity were found to produce a normalizing effect on the disturbances of the lipid composition. Thus, cholesterol indices normalized in 2-3 months.

[Spectrum of erythrocyte membrane lipids in various types of hypoglycemic therapy].

Changes in the lipid spectrum of red cell membrane (cholesterol, total and fractional phospholipids) were examined in 46 patients with newly detected non-insulin-dependent diabetes mellitus at the period of the disease diagnosis and over the course of therapy with various sugar-reducing drugs. Diabeton, a gliclazide series drug, has shown the most manifest compensatory effect on red cell membrane lipid shifts. Diets and biguanide therapy for 6-8 months failed to stably normalize the detected shifts; further correction appeared to be necessary in such cases.