Publications by authors named "Bryony Langford"
Introduction: Among the various types of progressive fibrosing interstitial lung diseases (PF-ILDs), substantial survival data exist for idiopathic pulmonary fibrosis (IPF) but not for other types. This hinders evidence-based decisions about treatment and management, as well as the economic modelling needed to justify research into new treatments and reimbursement approvals. Given the clinical similarities between IPF and other PF-ILDs, we reasoned that patient survival data from four major IPF trials could be used to estimate long-term survival in other PF-ILDs.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to assess the effectiveness of sodium-glucose co-transporter (SGLT) inhibitors and metformin as add-ons to insulin in type 1 diabetes (T1DM) through a network meta-analysis of phase 3 and 4 randomized controlled trials (RCTs).
- A systematic review found nine trials involving 6,780 participants, showing that SGLT inhibitors significantly reduced HbA1c levels and weight compared to metformin at 24 to 26 weeks.
- While the SGLT inhibitors demonstrated better efficacy, the safety profiles, including risks of diabetic ketoacidosis, showed no major differences and highlighted the need for direct comparison studies to confirm these findings.
Article Synopsis
- Up to 50% of essential tremor patients don't respond to medication, leading researchers to explore MRgFUS as an alternative treatment compared to other interventions like DBS and thalamotomy.
- A systematic review analyzed clinical and economic evidence, with a focus on safety and efficacy, revealing all treatments have varying effectiveness and safety profiles.
- The study found that MRgFUS shows comparable short-term benefits for tremor relief and quality of life to unilateral DBS, suggesting it could be a viable option for medication-refractory patients.
Background: Alkaptonuria (AKU) is a rare disorder with no licensed treatment; nitisinone may reduce symptoms and progression. The All Alkaptonuria Severity Score Index (AKUSSI) measures disease severity in clinical, joint and spine domains, with 57 subcomponent feature scores. Our primary aim was to assess tools for validating scores such as the AKUSSI by detecting relationships between features both before and during nitisinone treatment.
View Article and Find Full Text PDFBackground: Hyperkalaemia is a potentially life-threatening condition that can be managed with pharmacological and non-pharmacological approaches. With the recent development of new hyperkalaemia treatments, new information on safe and effective management of hyperkalaemia has emerged.
Objectives: This systematic literature review (SLR) aimed to identify all relevant comparative and non-comparative clinical data on management of hyperkalaemia in adults.