Publications by authors named "Bryna J Hazelton"
Background: Chromatographic peakpicking continues to represent a significant bottleneck in automated LC-MS workflows. Uncontrolled false discovery rates and the lack of manually-calibrated quality metrics require researchers to visually evaluate individual peaks, requiring large amounts of time and breaking replicability. This problem is exacerbated in noisy environmental datasets and for novel separation methods such as hydrophilic interaction columns in metabolomics, creating a demand for a simple, intuitive, and robust metric of peak quality.
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- Stomata are crucial structures on plant surfaces that help with gas exchange, and their formation and spacing are regulated by specific peptides from the EPF family.
- Researchers used a technique called Cre-lox recombination to study how these peptides, particularly EPF1 and Stomagen, impact stomatal patterns in plant epidermis.
- They created a computational tool called SPACE to analyze the effects of these peptides, finding that EPF1 has longer-range influences compared to Stomagen, and that local changes in stomatal development don’t significantly affect the overall stomatal patterns across the epidermis.