Publications by authors named "Bryanna Domenick"
Single-Center Survey of Prevalence of Viruses in Pediatric Liver Explants.
Pediatr Transplant
December 2024
Article Synopsis
- Adenovirus has been linked to acute liver failure (ALF), prompting a study on the prevalence of various viruses in children who underwent liver transplants due to liver diseases.
- The study analyzed 33 liver samples, finding HHV-6 in the majority of cases, while adenovirus was only detected in one ALF case, suggesting it may not significantly contribute to liver failure.
- The findings highlight HHV-6 as the most common virus in liver transplant cases, providing foundational data for understanding viral links to ALF.
Article Synopsis
- Hepatic artery complications (HACs) after pediatric liver transplantation can lead to significant health issues, and this study aims to understand how common they are, how they are managed, and what outcomes arise from these complications.
- The research utilizes the international HEPATIC Registry, collecting data on pediatric patients under 18 who experienced HAC within the last 20 years, focusing on survival rates and treatment success.
- Ethical approval will be obtained from all participating sites, and findings will be shared at conferences and in academic journals, with the study registered on ClinicalTrials.gov (NCT05818644).
Importance: Live vaccines (measles-mumps-rubella [MMR] and varicella-zoster virus [VZV]) have not been recommended after solid organ transplant due to concern for inciting vaccine strain infection in an immunocompromised host. However, the rates of measles, mumps, and varicella are rising nationally and internationally, leaving susceptible immunocompromised children at risk for life-threating conditions.
Objective: To determine the safety and immunogenicity of live vaccines in pediatric liver and kidney transplant recipients.