Publications by authors named "Bryana Belin"
Rates of burnout and compassion fatigue in healthcare professionals have remained high since the beginning of the pandemic with adverse implications for patient care. Tell Me More (TMM) is a tool licensed by the Gold Foundation, which was created with the purpose of helping patients, caregivers, and hospital staff to connect with each other on a humanistic level. Research has shown the benefits of the TMM with students and anecdotally with patients.
View Article and Find Full Text PDFThe currently accepted intestinal epithelial cell organization model proposes that Lgr5 crypt-base columnar (CBC) cells represent the sole intestinal stem cell (ISC) compartment. However, previous studies have indicated that Lgr5 cells are dispensable for intestinal regeneration, leading to two major hypotheses: one favoring the presence of a quiescent reserve ISC and the other calling for differentiated cell plasticity. To investigate these possibilities, we studied crypt epithelial cells in an unbiased fashion via high-resolution single-cell profiling.
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- Scientists found that special cells in the pancreas, called Tff2 cells, can help repair damage and keep the pancreas healthy.
- When the pancreas gets hurt, these Tff2 cells can reduce in number but can grow back later.
- If Tff2 cells are removed before cancer starts, it makes it easier for tumors to form, but adding Tff2 back can help protect against this cancer.
Adult enteric Dclk1-positive glial and neuronal cells reveal distinct responses to acute intestinal injury.
Am J Physiol Gastrointest Liver Physiol
June 2022
Intestinal ganglionic cells in the adult enteric nervous system (ENS) are continually exposed to stimuli from the surrounding microenvironment and need at times to respond to disturbed homeostasis following acute intestinal injury. The kinase DCLK1 and intestinal Dclk1-positive cells have been reported to contribute to intestinal regeneration. Although Dclk1-positive cells are present in adult enteric ganglia, their cellular identity and response to acute injury have not been investigated in detail.
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- Histidine decarboxylase (HDC) marks myeloid-biased hematopoietic stem cells (MB-HSCs) that respond to injury, but their role in acute colitis induced by DSS was previously unexplored.
- In experiments with HDC-GFP mice subjected to DSS treatment, researchers found that MB-HSCs rapidly activated and expanded during early inflammation but later depleted, causing HSC exhaustion and increased myeloid cell infiltration in the colon.
- Knocking out the HDC gene or removing HDC+ myeloid cells worsened this depletion, while H2-receptor agonist treatment preserved MB-HSCs and improved survival in DSS-treated mice, indicating a potential therapeutic approach. *
Article Synopsis
- Wild-caught animals often experience physiological changes related to stress and reproduction when taken into captivity, unlike those bred in labs.
- A study on house sparrows examined how captivity time affects the expression of specific stress and reproductive-associated genes in their brains, focusing on genes like CRH, GnIH, and the glucocorticoid receptor.
- Results showed that certain gene expressions adapted after 24 and 45 days in captivity, but by 66 days, adaptation levels matched those of wild-caught birds, indicating neuroendocrine adjustments occur faster than broader physiological changes.