Publications by authors named "Bryan Valcarcel"

Purpose: Lymphomas are a heterogeneous group of diseases that develop in individuals of all ages and have variable prognoses. Improved survival resulting from therapy advances has led to the emergence of diverse late effects. Although several (US)-based organizations have developed survivorship guidelines, the distinct features of lymphoma subtypes and diverse therapies used raise concerns regarding their applicability to lymphoma survivors.

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Acute myeloid leukemia (AML) often requires allogeneic hematopoietic cell transplantation (alloHCT) for cure, but historically alloHCT has been strikingly underutilized. Reasons for this remain uncertain at the population level. We examined alloHCT utilization over time and explored associations between demographic/healthcare factors and use of alloHCT by age group (AYA 15-39y, adult 40-64y, older adult 65-79y) using a linked dataset merging the Center for International Blood and Marrow Transplant Research, California Cancer Registry, and California Patient Discharge Database.

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Compared with the general population, hematopoietic cell transplantation (HCT) survivors are at elevated risk for developing solid subsequent neoplasms (SNs). The Center for International Blood and Marrow Transplant Research (CIBMTR) is a key resource for quantifying solid SN incidence following HCT, but the completeness of SN ascertainment is uncertain. Within a cohort of 18 450 CIBMTR patients linked to the California Cancer Registry (CCR), we evaluated the completeness of solid SN data reported to the CIBMTR from 1991 to 2018 to understand the implications of using CIBMTR data alone or combined with CCR data to quantify the burden of solid SNs after HCT.

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Purpose: Autologous hematopoietic cell transplantation (autoHCT) is associated with survival benefits in multiple myeloma (MM), but utilization remains low and differs by sociodemographic factors. Prior population-based studies have not fully captured autoHCT utilization or examined relationships between sociodemographic factors and autoHCT trends over time.

Patients And Methods: We used a novel data linkage between the California Cancer Registry, Center for International Blood and Marrow Transplant Research, and hospitalizations to capture autoHCT in a population-based MM cohort (n = 29, 109; 1991-2016).

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Article Synopsis
  • This study evaluates the challenges of tracking outcomes after hematopoietic cell transplantation (HCT) by comparing data from two sources: the Center for International Blood and Marrow Transplant Research (CIBMTR) and the California Cancer Registry (CCR).
  • It finds high agreement in patient vital status (97%+) but significant discrepancies in the cause of death reporting, with CIBMTR reporting more noncancer-related deaths and CCR showing a higher number of cancer-related deaths.
  • The analysis reveals that the CCR provides longer follow-up durations, indicating potential benefits of integrating cancer registry data to improve understanding of patient outcomes post-HCT.
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Background: In the last decades, an increasing incidence of testicular cancer has been observed in several countries worldwide. Although mortality rates have been variable in many countries, little information is available from Latin America and the Caribbean (LAC). Therefore, we examined mortality trends of testicular cancer in the last two decades.

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  • * A study of 90 AYAs in Peru showed a 91% overall response rate to R-CHOP, with 5-year overall survival (OS) and progression-free survival (PFS) rates of 79% and 67%, respectively.
  • * Despite comparable outcomes to adults, those with relapsed/refractory disease had poor prognosis, highlighting the need for better and more accessible treatment options for AYAs with DLBCL.
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Background: Previous studies have reported a higher prevalence of triple-negative breast cancer (TNBC) in US Hispanic/Latina populations. However, survival outcomes and treatment approaches over time in Latin American females are scarcely reported. We aimed to evaluate the temporal variation in treatment patterns and overall survival (OS) outcomes of females with TNBC according to cancer stage.

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  • * Among 118 patients treated between 2010 and 2019, those with RDW-CV values over 14% showed significantly lower overall survival rates (34% vs. 45%) and higher lymphoma-specific mortality (54% vs. 34%) over 4 years.
  • * The study suggests that high RDW-CV is a potential and easy-to-use prognostic marker for evaluating risk in PTCL patients, indicating a need for further validation in future research. *
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  • HTLV-1, an endemic virus in Latin America, is linked to worse outcomes in cancer patients, particularly those with adult T-cell leukemia/lymphoma (ATL) and non-ATL cancers.
  • A study analyzed 1,934 HTLV-1 carriers diagnosed with various cancers, finding that non-ATL malignancies, especially cervical cancer in females and non-Hodgkin lymphoma in males, had lower overall survival rates compared to the general population.
  • The research highlights the vulnerability of certain demographics, such as middle-aged individuals from underprivileged backgrounds, and calls for further investigation into HTLV-1's impact on cancer outcomes and the need for screening in affected regions.
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The promising results of the robotic approach for multiple cancer operations has led to interest in the potential of robotic nipple-sparing mastectomy (R-NSM); however, further studies are required to compare the benefits and complications of this approach with those of conventional open nipple-sparing mastectomy (C-NSM). We performed a meta-analysis to compare surgical complications of R-NSM versus C-NSM. We performed a review of literature through June 2022 in PubMed, Scopus, and EMBASE.

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Outcomes of females with triple-negative breast cancer (TNBC) are rarely explored in adolescents and young adults (AYAs). We compared clinical and survival outcomes of Latin American AYAs (≤39 years) with middle-aged (40-59 years) and older (≥60 years) females with TNBC by cancer stage. We performed a single-center retrospective cohort study among treated females with cancer stages I-III diagnosed from 2000 to 2014 in Peru.

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Background: An up-to-date analysis of gastric cancer mortality among Hispanic/Latino populations is required for estimating disease burden and assessing the effectiveness of clinical and preventive strategies.

Methods: We retrieved gastric cancer deaths between 1997 and 2017 (as available) from the Surveillance, Epidemiology, and End Results Program (United States Hispanics) and the World Health Organization databases (Puerto Rico, 16 Latin American and Caribbean countries). Joinpoint regression analysis was used to examine trends in age-standardized mortality rates (ASMR; per 100 000 person-years) and calculate average annual percent changes (AAPCs) by country (or territory), age group (25-49 and ≥50 years), and sex.

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Article Synopsis
  • The study analyzed prostate cancer mortality trends in Peru from 2003 to 2017 using data from the Ministry of Health.
  • A total of 38,617 prostate cancer deaths were reported, with a notable decline in mortality rates, especially in the coastal region, while the highlands and rainforest regions showed stable trends.
  • The findings highlight significant health care disparities across different geographical areas, emphasizing the need for targeted public health efforts to address the high mortality burden, particularly in rainforest provinces.
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Advances in hematopoietic cell transplantation (HCT) have substantially improved patient survival, increasing the importance of studying outcomes and long-term adverse effects in the rapidly growing population of HCT survivors. Large-scale registry data from the Center for International Blood and Marrow Transplant Research (CIBMTR) are a valuable resource for studying mortality and late effects after HCT, providing detailed data reported by HCT centers on transplantation-related factors and key outcomes. This study was conducted to evaluate the robustness of CIBMTR outcome data and assess health-related outcomes and healthcare utilization among HCT recipients.

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Purpose: Waldenstrom Macroglobulinemia (WM) is a rare lymphoma with distinct clinical features, and data from Latin American patients are lacking. Therefore, we aim to investigate the clinical, therapy, and outcome patterns of WM in Latin America.

Methods: We retrospectively analyzed patients with WM diagnosed between 1991 and 2019 from 24 centers in seven Latin American countries.

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Background: Childhood leukemia mortality is expected to increase in certain developing Latin American countries by 2030. The development of tailored public health interventions could benefit by understanding the role of healthcare system factors. Therefore, we aimed to evaluate the area-level association of healthcare system factors with leukemia mortality among Peruvian children aged 0-19.

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  • Lung cancer remains the leading cause of cancer-related deaths globally, with significant mortality rates reported in Peru, although accurate data is hindered by under-reporting.
  • A study analyzing lung cancer mortality trends from 2008 to 2017 in Peru found that mortality rates were higher in males, with regional differences showing declines on the coast but increases in the highlands, especially in Apurimac.
  • The analysis highlighted higher smoking prevalence in males, especially young adults, suggesting that public health measures targeting smoking reduction are essential to lower lung cancer mortality rates in the country.*
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  • The study investigates the survival outcomes of HTLV-1 carriers with diffuse large B-cell lymphoma (DLBCL) compared to non-carriers, focusing on overall survival (OS) and progression-free survival (PFS).
  • A total of 188 patients (66 HTLV-1 carriers and 122 non-carriers) were analyzed, revealing no significant difference in 5-year OS and PFS between the two groups.
  • The findings indicate that HTLV-1 infection does not worsen outcomes for DLBCL patients, suggesting standard treatment guidelines should apply to HTLV-1 seropositive patients.
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Adult T-cell leukemia/lymphoma (ATLL) is a largely incurable disease. Cutaneous involvement is common and could be first symptom of the disease. We analyzed 169 patients with ATLL of whom 63 had cutaneous involvement.

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Article Synopsis
  • * Researchers analyzed the medical records of 37 patients over 17 years, finding that those with community-acquired bacteremia had significantly lower overall survival rates within 30 days compared to those with healthcare-associated bacteremia.
  • * Key symptoms included abdominal pain, and the study suggested that community-acquired bacteremia presents a worse disease severity, which should help clinicians in prognosis determination for these patients.
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