Dynamical learning and tracking of tremor and dyskinesia from wearable sensors.

We have developed and evaluated several dynamical machine-learning algorithms that were designed to track the presence and severity of tremor and dyskinesia with 1-s resolution by analyzing signals collected from Parkinson's disease (PD) patients wearing small numbers of hybrid sensors with both 3-D accelerometeric and surface-electromyographic modalities. We tested the algorithms on a 44-h signal database built from hybrid sensors worn by eight PD patients and four healthy subjects who carried out unscripted and unconstrained activities of daily living in an apartment-like environment. Comparison of the performance of our machine-learning algorithms against independent clinical annotations of disorder presence and severity demonstrates that, despite their differing approaches to dynamic pattern classification, dynamic neural networks, dynamic support vector machines, and hidden Markov models were equally effective in keeping error rates of the dynamic tracking well below 10%.

High-resolution tracking of motor disorders in Parkinson's disease during unconstrained activity.

Parkinson's disease (PD) can present with a variety of motor disorders that fluctuate throughout the day, making assessment a challenging task. Paper-based measurement tools can be burdensome to the patient and clinician and lack the temporal resolution needed to accurately and objectively track changes in motor symptom severity throughout the day. Wearable sensor-based systems that continuously monitor PD motor disorders may help to solve this problem, although critical shortcomings persist in identifying multiple disorders at high temporal resolution during unconstrained activity.

Dynamic SVM detection of tremor and dyskinesia during unscripted and unconstrained activities.

In this paper, we report an experimental comparison of dynamic support vector machines (SVMs) to dynamic neural networks (DNNs) in the context of a system for detecting dyskinesia and tremor in Parkinson's disease (PD) patients wearing accelerometer (ACC) and surface electromyographic (sEMG) sensors while performing unscripted and unconstrained activities of daily living. These results indicate that SVMs and DNNs of comparable computational complexities yield approximately identical performance levels when using an identical set of input features.

Detecting freezing-of-gait during unscripted and unconstrained activity.

We present a dynamic neural network (DNN) solution for detecting instances of freezing-of-gait (FoG) in Parkinson's disease (PD) patients while they perform unconstrained and unscripted activities. The input features to the DNN are derived from the outputs of three triaxial accelerometer (ACC) sensors and one surface electromyographic (EMG) sensor worn by the PD patient. The ACC sensors are placed on the shin and thigh of one leg and on one of the forearms while the EMG sensor is placed on the shin.

What is IPUS and how does it help resolve biosignal complexity?

Integrated Processing and Understanding of Signals (IPUS) combines signal processing and artificial intelligence approaches to develop algorithms for resolving signal complexity. It has also led to development over the last decade and a half of software tools for supporting the algorithm design process. The signals to be analyzed are the superposition of temporally localized and temporally overlapping signal components from broadly defined signal classes pertinent to the given application.

Resolving signal complexities for ambulatory monitoring of motor function in Parkinson's disease.

Automatic tracking of movement disorders in patients with Parkinson's disease (PD) is dependent on the ability of machine learning algorithms to resolve the complex and unpredictable characteristics of wearable sensor data. The challenge reflects the variety of movement disorders that fluctuate throughout the day which can be confounded by voluntary activities of daily life. Our approach is the development of multiple dynamic neural network (DNN) classifiers whose application are governed by a rule-based controller within the Integrated Processing and Understanding of Signals (IPUS) framework.

Resolving signal complexities for ambulatory monitoring of motor function in Parkinson's disease.

Automatic tracking of movement disorders in patients with Parkinson's disease (PD) is dependent on the ability of machine learning algorithms to resolve the complex and unpredictable characteristics of wearable sensor data. The challenge reflects the variety of movement disorders that fluctuate throughout the day which can be confounded by voluntary activities of daily life. Our approach is the development of multiple dynamic neural network (DNN) classifiers whose application are governed by a rule-based controller within the Integrated Processing and Understanding of Signals (IPUS) framework.

Dynamic neural network detection of tremor and dyskinesia from wearable sensor data.

We present a dynamic neural network (DNN) solution for detecting time-varying occurrences of tremor and dyskinesia at 1 s resolution from time series data acquired from surface electromyographic (sEMG) sensors and tri-axial accelerometers worn by patients with Parkinson's disease (PD). The networks were trained and tested on separate datasets, each containing approximately equal proportions of tremor, dyskinesia, and disorder-free data from 8 PD and 4 control subjects performing unscripted and unconstrained activities in an apartment-like environment. During DNN testing, tremor was detected with a sensitivity of 93% and a specificity of 95%, while dyskinesia was detected with a sensitivity of 91% and a specificity of 93%.