Publications by authors named "Bryan Stender"
Article Synopsis
- - Undergraduate students at UCLA conducted research using RNA interference (RNAi) and fluorescent proteins to pinpoint genes crucial for blood cell development in fruit flies, screening around 3,500 genes and finding 137 that affected hematopoiesis.
- - By targeting RNAi to different cell types involved in blood cell maturation, the researchers identified specific gene subsets that either facilitate or inhibit this process, revealing new insights into gene functions related to RNA processing and vesicular trafficking.
- - The CURE (Course-Based Undergraduate Research Experience) model not only enhanced students' understanding and skills in science but also improved retention rates in STEM fields, demonstrating the value of hands-on research in education.
Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin.
Proc Natl Acad Sci U S A
August 2016
Microrchidia (MORC) proteins are GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPases that function in gene regulation in multiple organisms. Animal MORCs also contain CW-type zinc finger domains, which are known to bind to modified histones. We solved the crystal structure of the murine MORC3 ATPase-CW domain bound to the nucleotide analog AMPPNP (phosphoaminophosphonic acid-adenylate ester) and in complex with a trimethylated histone H3 lysine 4 (H3K4) peptide (H3K4me3).
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