Publications by authors named "Bryan Spencer"

Article Synopsis
  • - COVID-19 convalescent plasma (CCP) may be beneficial for immunocompromised patients, but the FDA's current threshold for qualifying plasma based on antibody levels might be too low.
  • - A study evaluated antibody levels in blood donors with different infection and vaccination histories, revealing that those with hybrid immunity (infection followed by vaccination) had higher antibody levels and better neutralizing capabilities.
  • - The research suggests establishing new test-based criteria for qualifying CCP, highlighting that plasma with high antibody levels could effectively neutralize various COVID-19 variants for several months after infection or vaccination.
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  • - The study investigates the prevalence of long-term symptoms in blood donors based on their SARS-CoV-2 infection status, focusing on differences across various occupations and industries.
  • - Data was collected from nearly 28,000 donors, revealing that 45% of those previously infected reported new long-term symptoms, compared to 24% of those never infected, with higher symptom prevalence in certain job sectors like healthcare support and accommodation services.
  • - The findings suggest that certain occupational groups experience more long-term symptoms due to their exposure to COVID-19, indicating a potential need for workplace accommodations to support affected employees.
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  • Blood donations have played a critical role in advancing public health understanding, especially highlighted during the SARS-CoV-2 pandemic, which showed the potential for blood services to contribute to public health surveillance and research.
  • The International Society of Blood Transfusion (ISBT) created a Public Health Research Toolkit to support blood services and researchers in expanding their involvement in public health initiatives.
  • This toolkit offers resources and templates for blood services to leverage donor data, engage in research studies, and establish biobanks, ultimately aiming to enhance recognition and funding for public health contributions.
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  • Long COVID is a complex condition affecting about 12% of COVID-19 survivors, with various symptoms and no widely accepted definition, pushing researchers to study its immune profile.
  • A survey of over 33,000 blood donors revealed that higher levels of anti-nucleocapsid antibodies are linked to an increased risk of long COVID, while higher anti-spike IgG levels can reduce that risk.
  • The study identified four clinical subphenotypes—ranging from neurological to multi-systemic symptoms—suggesting that different immune responses may contribute to varied long COVID experiences.
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Article Synopsis
  • * A study involving 142,599 blood donors established a new, lower threshold for detecting past infections using the Ortho VITROS Anti-SARS-CoV-2 Total-N Antibody assay, which boosted detection sensitivity while keeping specificity above 98%.
  • * The updated test showed a high sensitivity of 98.1% for unvaccinated individuals and 95.6% for those who were vaccinated, though sensitivity was influenced by factors like the virus variant, donor age,
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In the age of global climate change, extreme climatic events are expected to increase in frequency and severity. Animals will be forced to cope with these novel stressors in their environment. Glucocorticoids (i.

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Article Synopsis
  • The study focuses on COVID-19 mitigation measures in workplaces where U.S. blood donors are employed, analyzing how these measures differ by industry and work arrangement.
  • Data was collected from over 53,000 respondents between May and December 2021, revealing varied implementation of measures like ventilation upgrades (20% overall), telework access (53% overall), and mask requirements (84% overall), with fewer measures reported by independent workers.
  • The findings suggest that mitigation strategies should be customized for specific industries and job types, as a uniform approach may not effectively address unique workplace challenges related to disease transmission.
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Community-engaged research often poses challenges due to exactly those qualities that make it desirable: it provides a new model of research that differs in many ways from top-down, university-led, prospectively designed approaches. While many have discussed the challenges to conducting community-engaged research, few have provided precise and generalizable lessons for how to surmount these challenges. Here we discuss the challenges experienced in a project that was community-engaged at three levels: 1) a research team consisting of an academic and a community partner as well as a community and academic research assistant, 2) the research team engaged with a Community Advisory Board called the CBOP-CERB (Community Based Organization Partners-Community Ethics Research Board) throughout the project, and 3) the research involved recruiting community participants from an area with a historical distrust of researchers and research: Flint Michigan.

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In recognition of the importance of evaluation for funding, research, and quality improvement, a longstanding Community Advisory Board in Flint Michigan embarked on a process to evaluate their impact. The Community-Based Organization Partners (CBOP)-Community Ethics Review Board (CERB) engaged a research team composed of an academic researcher (Solomon Cargill) and a community partner (Spencer) to obtain funding, design and implement an evaluation of the CBOP-CERB. This evaluation study yielded two evaluations of the CBOP-CERB, one with researchers who had engaged with the CBOP-CERB and the other with Flint area community residents.

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Article Synopsis
  • - The study investigates the prevalence of long-term health symptoms following SARS-CoV-2 infection, addressing the gap of previous research that lacked control groups uninfected by the virus.
  • - Conducted among American Red Cross blood donors, the cross-sectional study involved surveys and serologic testing to assess new symptoms from March 2020 onwards, focusing on neurological, gastrointestinal, respiratory, cardiac, and mental health issues.
  • - Results showed that 43.3% of individuals with a history of SARS-CoV-2 infection reported new long-term symptoms, significantly higher than the 22.1% in those without such a history, suggesting a strong link between COVID-19 and the development of these symptoms.
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Serial blood and mucosal samples were characterized for 102 participants enrolled a median of 7.0 days after coronavirus disease 2019 diagnosis. Mucosal RNA was detectable for a median of 31.

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Patients treated with antineoplastic therapy often develop thrombocytopenia requiring platelet transfusion, which has potential to exacerbate pulmonary injury. This study tested the hypothesis that amotosalen-UVA pathogen-reduced platelet components (PRPCs) do not potentiate pulmonary dysfunction compared with conventional platelet components (CPCs). A prospective, multicenter, open-label, sequential cohort study evaluated the incidence of treatment-emergent assisted mechanical ventilation initiated for pulmonary dysfunction (TEAMV-PD).

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Importance: China has experienced both rapid urbanization and major increases in myopia prevalence. Previous studies suggest that green space exposure reduces the risk of myopia, but the association between myopia risk and specific geometry and distribution characteristics of green space has yet to be explored. These must be understood to craft effective interventions to reduce myopia.

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Article Synopsis
  • The study looked into the safety of transfusing plasma or platelets that contain SARS-CoV-2 antibodies to hospitalized patients who do not have COVID-19, during different phases of the pandemic.
  • Researchers analyzed data from over 21,000 hospitalizations across pre-COVID, pre-vaccine, and post-vaccine periods to see if there were any changes in health outcomes related to transfusions.
  • The results indicated that there were no significant increases in thrombotic events, oxygen requirements, ICU stays, hospital mortality, or rehospitalizations due to plasma or platelet transfusions, regardless of the pandemic period.
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  • The study examines how work as a social determinant affects COVID-19 infection rates across different industries, noting that previous analyses have been limited and mostly self-reported.
  • From May to December 2021, researchers analyzed blood samples and conducted surveys on 57,726 donors, finding a 12% seroprevalence of prior SARS-CoV-2 infection, with the highest rates in sectors like Accommodation & Food Services and Mining.
  • The findings highlight that certain industries were more severely impacted by COVID-19, suggesting the need for tailored public health strategies to address health disparities related to workplace environments.
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  • Malaria is a disease caused by tiny bugs called Plasmodium, which are spread by mosquitoes, and in the US, blood donors are asked about their travel history for malaria before donating blood.
  • A special test called the Procleix Plasmodium Assay was developed to find signs of malaria in blood, and it was checked on thousands of blood samples to see how well it works.
  • The results showed that this test is really good at detecting malaria, even in healthy people who don't show symptoms, and it might help reduce the number of donors who have to wait before giving blood due to malaria concerns.
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Communities of color and diverse communities (eg, race, socioeconomic status, language, sexual orientation etc.) have not been recruited and enrolled equitably to participate in research studies in transfusion medicine. The exclusion of diverse communities in transfusion research can lead to health disparities lack of access to approved therapeutics and unequal allocation of interventions, resulting in missed opportunities to optimize health for individuals and communities.

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Introduction: is a tick-borne intraerythrocytic parasite that is globally ubiquitous, yet understudied. Several species of have been shown to be transfusion-transmissible. has been reported in blood donors, animals, and ticks in the Tyrol (Western Austria), and regional cases of human babesiosis have been described.

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Article Synopsis
  • A study tested plasma samples from 1596 donors who reported COVID-19 symptoms after donating blood for SARS-CoV-2 RNA and specific antibodies.* -
  • Results showed that having prior infection or vaccination provided protection against developing SARS-CoV-2 RNAemia and symptomatic infection.* -
  • The rates of RNAemia remained consistent regardless of whether the samples were taken during the Delta or Omicron variant phases.*
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Background: Blood donors were tested for antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); resulting antibody levels were monitored over time.

Methods: Donors reactive to anti-SARS-CoV-2 spike protein (S1-total antibodies) participated in a follow-up study of 18 months. Testing for nucleocapsid antibodies distinguished between vaccination and infection.

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Background: Iron supplementation (IS) improves blood donors' iron stores and allows more frequent blood donation. Understanding the accuracy of self-reported IS is helpful for potential application of IS practices to donor eligibility or donation intervals.

Methods: Successful whole blood and red cell apheresis donors completed a survey at donation on the use of select dietary supplements.

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Blood collection from minority populations improves the transfusion support of patients with sickle cell disease and thalassemia, but efforts are challenged by high deferral rates for hemoglobin (Hb) eligibility thresholds. This study sought to evaluate hemoglobin and iron status of a representative US female population to assess the suitability of 12.0 g/dL as minimum hemoglobin.

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