The article by Albrow et al in this issue describes the early cervical screening program in England as being "disorganized," but goes on to describe significant improvements over 20 years. It has become one of the leading screening programs in the developed world. Liquid-based technology has been embraced, but image analysis has not.
View Article and Find Full Text PDFClinical use of tissue microarrays for immunohistochemical analysis of breast biomarkers, namely estrogen receptor, progesterone receptor, and HER2, was instituted in our laboratory in 2008. The method has proved reliable and cost-effective. We report the results of the initial year of testing with this method.
View Article and Find Full Text PDFTissue microarray analysis (TMA) allows multiple analyses on multiple patients on sections from a single paraffin block. Although it is widely used in research and in quality assurance settings, there are few references to its use in clinical practice. This study evaluated TMA assessment of breast biomarkers using immunohistochemical analysis in a clinical histopathology laboratory.
View Article and Find Full Text PDFAppl Immunohistochem Mol Morphol
October 2009
Immunohistochemistry results for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are used to guide breast carcinoma patient management and it is essential to monitor these tests in external quality assurance (EQA) programs. Canadian Immunohistochemistry Quality Control is a web-based program with novel approach to EQA. Canadian Immunohistochemistry Quality Control RUN2 included tissue microarray slides with 38 samples tested by 18 immunohistochemical laboratories.
View Article and Find Full Text PDFIn South Africa, carcinoma of the cervix affects 1 in 29 women. A national screening programme to address the problem has been implemented. The programme faces serious challenges including shortage of funds, a lack of trained laboratory personnel and the HIV epidemic.
View Article and Find Full Text PDFObjectives: The obligate intracellular bacterium Chlamydia trachomatis is frequently found in association with benign proliferative, pre-neoplastic and malignant changes in cervical epithelium. The present study addresses the possible role of C. trachomatis infection of the uterine cervix in modulating human cancer gene expression.
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