Crowdsourcing Electronic Health Record Improvements at Scale across an Integrated Health Care Delivery System.

Background And Objective: Despite widespread adoption of electronic health records (EHRs), these systems have significant room for improved efficiency and efficacy. While the idea of crowdsourcing EHR improvement ideas has been reported, little is known about how this might work across an integrated health care delivery system in practice.

Methods: Our program solicited EHR improvement submissions during two timeframes across 10 hospitals and 60 clinics in an upper-Midwest integrated health care delivery system.

Overcoming gaps: regional collaborative to optimize capacity management and predict length of stay of patients admitted with COVID-19.

Objective: Ensuring an efficient response to COVID-19 requires a degree of inter-system coordination and capacity management coupled with an accurate assessment of hospital utilization including length of stay (LOS). We aimed to establish optimal practices in inter-system data sharing and LOS modeling to support patient care and regional hospital operations.

Materials And Methods: We completed a retrospective observational study of patients admitted with COVID-19 followed by 12-week prospective validation, involving 36 hospitals covering the upper Midwest.

Assessing Provider-Generated Free-Text Quality in EHR-Integrated Handoff Notes.

Handoff notes are increasingly integrated within electronic health record (EHR) systems and often contain data automatically generated from the EHR and free-text narratives. We examined the quality of data entered by providers in the free-text portion of our institutional EHR handoff tool. Overall, 65% of handoff notes contained at least one error (average 1.

Regulation of proteins affecting NMDA receptor-induced excitotoxicity in a Huntington's mouse model.

Symptoms of Huntington's disease may be caused by a toxic insult triggered by the mutant human huntingtin (Htt) protein itself, by a maladaptive protective mechanism initiated in response to an insult, or by a combination of these. We observed a protection from N-methyl-d-aspartate (NMDA) receptor-induced excitotoxicity in striata of symptomatic N171-82Q mice, a new transgenic model of Huntington's disease. The goal of this study was to determine if NMDA receptor-mediated signalling pathways are altered in these mice.

Association of NR3A with the N-methyl-D-aspartate receptor NR1 and NR2 subunits.

The NR3A subunit of the N-methyl-D-aspartate receptor has been shown to form glutamatergic receptor complexes with NR1 and NR2 subunits and excitatory glycinergic receptor complexes with NR1 alone. We developed an antibody to NR3A and, using quantitative immunoblotting techniques, determined the degree of association between the NR3A subunit and the NR1 and NR2 subunits as well as changes in these associations during development. NR3A expression peaks between postnatal days 7 and 10 in the cortex, midbrain, and hippocampus and reaches higher maximal expression levels in these areas than in the olfactory bulb and cerebellum.

Tris(benzylthiolato)bismuth. Efficient Precursor to Phase-Pure Polycrystalline Bi(2)S(3).

Details of the synthesis, physical and spectroscopic characterization, and thermal decomposition of tris(benzylthiolato)bismuth, (BnS)(3)Bi, Bn = CH(2)C(6)H(5), are presented. Results from pyrolysis of (BnS)(3)Bi demonstrate that this compound is a convenient precursor to phase-pure, polycrystalline Bi(2)S(3) with low carbon and hydrogen contamination under mild thermal conditions (ca. 275 degrees C).