The forehead flap: the gold standard of nasal soft tissue reconstruction.

The forehead flap is one of the oldest recorded surgical techniques for nasal reconstruction. As the gold standard for nasal soft tissue reconstruction, the forehead flap provides a reconstructive surgeon with a robust pedicle and large amount of tissue to reconstruct almost any defect. Modifications provided by masters like Burget and Menick have only increased the utility of this exceptional flap.

Transconjunctival midface lift: a "hole" different fixation.

Background: Improvements in midfacial rejuvenation have allowed for more predictable and reliable results; however, there are still common problems that can lead to a suboptimal outcome. Specifically, we aim to achieve an appropriate vector of lift, adequate camouflaging of the nasojugal groove, especially medially, as well as to obtain a durable, long-term result.

Objective: We aim to demonstrate that utilizing bony fixation to obtain midface lift will allow for better control of vector placement as well as lead to a more durable result and, thus, a better long-term outcome.

DNA sequence recognition by Hoechst 33258 conjugates of hairpin pyrrole/imidazole polyamides.

A series of hairpin pyrrole/imidazole polyamides linked to a Hoechst 33258 (Ht) analogue (5-7) were synthesized on solid-phase by adopting an Fmoc technique using a series of PyBOP/HOBt mediated coupling reactions. The dsDNA binding properties of Ht-polyamides 5-7 were determined by thermal denaturation experiments. Hairpin Ht-polyamides 5-7 bound to dsDNA sequences 16 and 18 show DeltaTm values that are 14-18 degrees higher than linear Ht-polyamides bound to the same sequences.