Publications by authors named "Bryan Hannon"
Article Synopsis
- - The opioid overdose epidemic is worsening due to the prevalence of fentanyl and its analogues in illicit drugs, prompting the need for better treatment options.
- - This study focuses on the isolation and efficacy of two families of monoclonal antibodies (mAbs) designed to target fentanyl and carfentanil, revealing that humanizing these mAbs reduced their effectiveness.
- - Structural analysis identified a key residue, Tyr36, in murine mAbs that is vital for binding to fentanyl and carfentanil, highlighting the significance of structural insights in engineering mAbs for opioid treatment.
