The effects of hepatitis C, HIV, and methamphetamine dependence on neuropsychological performance: biological correlates of disease.

Objective: To determine the effects of hepatitis C virus (HCV) infection on neuropsychological (NP) performance.

Design: Cross-sectional analysis of a prospectively enrolled cohort.

Methods: A total of 239 HIV-seropositive and 287 HIV-seronegative subjects enrolled in prospective cohort studies at a single center.

Lopinavir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for HIV.

Introduction: Lopinavir (LPV) is highly bound to plasma proteins and is a substrate for active drugs transporters, which may greatly limit the access of LPV to the central nervous system (CNS). However, even low lopinavir concentrations may be sufficient to inhibit HIV replication. Prior anecdotal reports indicated that lopinavir concentrations were below detection in cerebrospinal fluid (CSF).