Publications by authors named "Bruyere Olivier"

The European Geriatric Medicine Society (EuGMS) will publish clinical guidelines grounded in evidence-based knowledge pertaining to identification, prevention, diagnosis and management of conditions that are relevant to older people. The primary goal is to produce relevant recommendations that address areas not currently covered by organ-based clinical guidelines, thereby mitigating uncertainty and enhancing the quality of care for older patients, in particular those with multimorbidity and frailty. This document, approved by the Academic Board and the Executive Board of the EuGMS, informs on the creation and organization of the Guideline Committee, the procedures to develop clinical guidelines, methodological aspects and ethical issues related to their production and dissemination.

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Rationale: This study evaluates TBS for estimating bone microarchitecture in ESRD patients using HR-pQCT as the reference technique.

Main Results: TBS correlates significantly with vBMD and bone microarchitecture, unlike aBMD.

Significance: TBS may complement bone health assessment in ESRD patients by offering additional information alongside aBMD.

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Background: Sarcopenia is a progressive muscle disorder that may lead to mobility disability. No pharmaceutical interventions are currently available, and treatment relies on physical exercise and nutrition. The aim of SARA-INT was to investigate whether BIO101 (20-hydroxyecdysone), an activator of the MAS receptor, is safe and improves muscle function and physical performance of community dwelling older sarcopenic patients.

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Osteoporosis and osteoarthritis are key diseases of musculoskeletal ageing and are increasing in prevalence and burden with the progressively ageing population worldwide. These conditions are thus particularly common in 'the oldest old', and there are complexities of managing them within the context of extensive multimorbidity, physical and mental disability, and polypharmacy, the rates for all of which are high in this population. In this narrative review, we explore the epidemiology of osteoporosis and osteoarthritis in the oldest old before examining trials and real-world data relating to the pharmacological treatment of these diseases in older adults, including anti-resorptives and bone-forming agents in osteoporosis and symptomatic slow-acting drugs for osteoarthritis, paracetamol, and non-steroidal anti-inflammatory drugs in osteoarthritis, recognising that the oldest old are usually excluded from clinical trials.

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Unlabelled: The relationship between rheumatoid arthritis (RA) and fracture risk was estimated in an international meta-analysis of individual-level data from 29 prospective cohorts. RA was associated with an increased fracture risk in men and women, and these data will be used to update FRAX®.

Introduction: RA is a well-documented risk factor for subsequent fracture that is incorporated into the FRAX algorithm.

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Background: The prevalence of sarcopenia is high among older adults residing in long-term care settings (LTCS). Guidelines to manage sarcopenia cannot be directly implemented among sarcopenic older adults residing in LTCS.

Objectives: To examine the effectiveness of a codesigned Reablement Strategies targeting Sarcopenia (ReStart-S) program on muscle parameters, physical performance, blood biomarkers and quality of life among sarcopenic older adults residing in LTCS.

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Background And Aims: Frailty is common among hemodialysis (HD) patients. Its assessment is usually based on clinical criteria. In the present work, we evaluated the interest of combining clinical frailty score and biomarkers to predict mortality of chronic HD patients.

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The objective of this systematic review and meta-analysis was to assess the carcinogenic effects of extremely low frequency magnetic fields (ELF-MF) by analyzing animal and comet assay studies. We have performed a global meta-analysis on all the animal studies on the relation between ELF-MF and cancer incidence and separate meta-analyses on the incidence of cancer, leukemia, lymphoma, breast cancer, brain cancer and DNA damage assessed with the comet assay. Of the 5145 references identified, 71 studies have been included in our systematic review and 22 studies in our meta-analyses.

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Mild cognitive impairment, dementia and osteoporosis are common diseases of ageing and, with the increasingly ageing global population, are increasing in prevalence. These conditions are closely associated, with shared risk factors, common underlying biological mechanisms and potential direct causal pathways. In this review, the epidemiological and mechanistic links between mild cognitive impairment, dementia and skeletal health are explored.

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Article Synopsis
  • A previous trial found that taking 800 mg/day of chondroitin sulfate (CS) significantly reduced pain and improved function in patients with knee osteoarthritis over 6 months compared to a placebo.
  • The current study aimed to analyze the cost-effectiveness of CS in Europe by evaluating individual patient data from the trial, using measures like quality-adjusted life years (QALYs) and the incremental cost-effectiveness ratio (ICER).
  • Results showed that CS treatment had an average cost of around 194.74 EUR over 6 months and an ICER of 33,462 EUR per QALY gained, indicating that CS is cost-effective compared to placebo.
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  • The study investigates the vitamin D metabolite ratio (VMR) as a potential better indicator of vitamin D deficiency compared to 25-hydroxyvitamin D (25(OH)D) and 24,25-dihydroxyvitamin D (24,25(OH)D), aiming to show its stronger correlation with parathyroid hormone (PTH) levels and mortality.
  • It analyzed serum samples from 204 older adults, demonstrating that VMR had the strongest negative correlation with PTH levels and was associated with higher mortality rates in patients with low levels.
  • The results suggest that VMR could be a more reliable biomarker for assessing functional vitamin D deficiency, supporting its potential use in clinical practice.
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Article Synopsis
  • Low vitamin D levels are linked to various health problems, making people and doctors interested in checking vitamin D levels more often.
  • Most health guidelines don't suggest checking vitamin D levels for everyone, but rather for specific groups who might need it the most.
  • There are many different opinions on how to test for vitamin D, and it's important to align these guidelines to make testing easier and more effective for everyone.
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  • Bone forming agents are important treatments for people with osteoporosis who have a very high risk of getting fractures.
  • Doctors need to identify the right patients who will benefit the most from these treatments, especially those with severe osteoporosis or recent fractures.
  • Using these agents can help strengthen bones and reduce fracture risk, and after treatment, patients should switch to other therapies to keep their bones strong.
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  • The Nursing Home Culture Change (NHCC) movement tries to make nursing homes feel more like home and focus on relationships between people.
  • A study looked at how NHCC affects residents, staff, families, and the nursing homes themselves, finding it has mostly good effects.
  • Future research is needed to figure out what makes it hard to use these changes, look at costs, and improve how nursing home staff are educated and supported.
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Objectives: The global increase in the older population, which is expected to reach 1.5 billion by 2050, poses significant challenges for publicly funded health care systems. Life expectancy, although positive, is leading to an increase in chronic diseases requiring complex and costly health and social solutions.

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Objective: This study aimed to map the Lequesne index onto the EuroQol 5 Dimension (EQ-5D-5L) utility index for patients with knee osteoarthritis.

Methods: Baseline data from a previous randomized controlled trial were used; 461 patients were involved in the mapping development, and 230 in the validation phase. Various modeling techniques, including generalized linear models, tobit, and beta regression, were used.

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Article Synopsis
  • * The authors advocate for keeping ethnic and race-specific FRAX models in the US, suggesting they should be based on updated data related to fracture and death risks.
  • * The position opposing fixed bone mineral density thresholds is supported by the International Osteoporosis Foundation (IOF) and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), emphasizing the need for equity in fracture risk assessment.
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Radiofrequency Echographic Multi Spectrometry (REMS) is a radiation-free, portable technology, which can be used for the assessment and monitoring of osteoporosis at the lumbar spine and femoral neck and may facilitate wider access to axial BMD measurement compared with standard dual-energy x-ray absorptiometry (DXA).There is a growing literature demonstrating a strong correlation between DXA and REMS measures of BMD and further work supporting 5-year prediction of fracture using the REMS Fragility Score, which provides a measure of bone quality (in addition to the quantitative measure of BMD).The non-ionising radiation emitted by REMS allows it to be used in previously underserved populations including pregnant women and children and may facilitate more frequent measurement of BMD.

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Preventing falls in older adults requires a comprehensive approach that distinguishes between accidental falls and falls related to underlying medical problems, such as syncope. For unintentional falls, prevention follows a three-stage model. The primary level focuses on encouraging regular physical activity, assessing, and reducing footwear and environmental risks, managing comorbidities, and promoting healthy lifestyles.

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Background: Low grip strength and gait speed are associated with mortality. However, investigation of the additional mortality risk explained by these measures, over and above other factors, is limited.

Aim: We examined whether grip strength and gait speed improve discriminative capacity for mortality over and above more readily obtainable clinical risk factors.

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Background: Health literacy (HL) has been put forward as a potential mediator through which socioeconomic status (SES) affects health. This study explores whether HL mediates the relation between SES and a selection of health or health-related outcomes.

Methods: Data from the participants of the Belgian health interview survey 2018 aged 18 years or older were individually linked with data from the Belgian compulsory health insurance (n = 8080).

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Objectives: To evaluate some confounding factors that influence the concentrations of S100 calcium binding protein B (S100B), glial fibrillary acidic protein (GFAP), and ubiquitin carboxyl-terminal hydrolase L-1 (UCH-L1) in older individuals. Indeed, recent guidelines have proposed the combined use of S100B and the "GFAP-UCH-L1" mTBI test to rule out mild traumatic brain injuries (mTBI). As older adults are the most at risk of mTBI, it is particularly important to understand the confounding factors of those mTBI rule-out biomarkers in aging population.

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