Publications by authors named "Bruyere O"
The objective of this systematic review and meta-analysis is to assess the carcinogenic effects of extremely low frequency magnetic fields (ELF-MF) by analyzing animal and comet assay studies. We have performed a global meta-analysis on all the animal studies on the relation between ELF-MF and cancer incidence and separate meta-analyses on the incidence of cancer, leukemia, lymphoma, breast cancer, brain cancer and DNA damage assessed with the comet assay. Of the 5145 references identified, 71 studies have been included in our systematic review and 22 studies in our meta-analyses.
View Article and Find Full Text PDFMild cognitive impairment, dementia and osteoporosis are common diseases of ageing and, with the increasingly ageing global population, are increasing in prevalence. These conditions are closely associated, with shared risk factors, common underlying biological mechanisms and potential direct causal pathways. In this review, the epidemiological and mechanistic links between mild cognitive impairment, dementia and skeletal health are explored.
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- A previous trial found that taking 800 mg/day of chondroitin sulfate (CS) significantly reduced pain and improved function in patients with knee osteoarthritis over 6 months compared to a placebo.
- The current study aimed to analyze the cost-effectiveness of CS in Europe by evaluating individual patient data from the trial, using measures like quality-adjusted life years (QALYs) and the incremental cost-effectiveness ratio (ICER).
- Results showed that CS treatment had an average cost of around 194.74 EUR over 6 months and an ICER of 33,462 EUR per QALY gained, indicating that CS is cost-effective compared to placebo.
Article Synopsis
- The study investigates the vitamin D metabolite ratio (VMR) as a potential better indicator of vitamin D deficiency compared to 25-hydroxyvitamin D (25(OH)D) and 24,25-dihydroxyvitamin D (24,25(OH)D), aiming to show its stronger correlation with parathyroid hormone (PTH) levels and mortality.
- It analyzed serum samples from 204 older adults, demonstrating that VMR had the strongest negative correlation with PTH levels and was associated with higher mortality rates in patients with low levels.
- The results suggest that VMR could be a more reliable biomarker for assessing functional vitamin D deficiency, supporting its potential use in clinical practice.
Article Synopsis
- Low vitamin D levels are linked to various health problems, making people and doctors interested in checking vitamin D levels more often.
- Most health guidelines don't suggest checking vitamin D levels for everyone, but rather for specific groups who might need it the most.
- There are many different opinions on how to test for vitamin D, and it's important to align these guidelines to make testing easier and more effective for everyone.
Article Synopsis
- Bone forming agents are important treatments for people with osteoporosis who have a very high risk of getting fractures.
- Doctors need to identify the right patients who will benefit the most from these treatments, especially those with severe osteoporosis or recent fractures.
- Using these agents can help strengthen bones and reduce fracture risk, and after treatment, patients should switch to other therapies to keep their bones strong.
Spat collection of the pearl oyster Pinctada margaritifera in atoll lagoons of French Polynesia is the fundamental sustain of black pearl farming. Spat collection has always yielded variable results in space and time, but obvious signs of steady decreases, even collapses, have emerged in several lagoons. Spat collection materializes the ecological connectivity pathways between wild spawning populations and the location of artificial larval settlement substrates.
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- The Nursing Home Culture Change (NHCC) movement tries to make nursing homes feel more like home and focus on relationships between people.
- A study looked at how NHCC affects residents, staff, families, and the nursing homes themselves, finding it has mostly good effects.
- Future research is needed to figure out what makes it hard to use these changes, look at costs, and improve how nursing home staff are educated and supported.
Objectives: The global increase in the older population, which is expected to reach 1.5 billion by 2050, poses significant challenges for publicly funded health care systems. Life expectancy, although positive, is leading to an increase in chronic diseases requiring complex and costly health and social solutions.
View Article and Find Full Text PDFObjective: This study aimed to map the Lequesne index onto the EuroQol 5 Dimension (EQ-5D-5L) utility index for patients with knee osteoarthritis.
Methods: Baseline data from a previous randomized controlled trial were used; 461 patients were involved in the mapping development, and 230 in the validation phase. Various modeling techniques, including generalized linear models, tobit, and beta regression, were used.
Article Synopsis
- * The authors advocate for keeping ethnic and race-specific FRAX models in the US, suggesting they should be based on updated data related to fracture and death risks.
- * The position opposing fixed bone mineral density thresholds is supported by the International Osteoporosis Foundation (IOF) and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), emphasizing the need for equity in fracture risk assessment.
Radiofrequency Echographic Multi Spectrometry (REMS) is a radiation-free, portable technology, which can be used for the assessment and monitoring of osteoporosis at the lumbar spine and femoral neck and may facilitate wider access to axial BMD measurement compared with standard dual-energy x-ray absorptiometry (DXA).There is a growing literature demonstrating a strong correlation between DXA and REMS measures of BMD and further work supporting 5-year prediction of fracture using the REMS Fragility Score, which provides a measure of bone quality (in addition to the quantitative measure of BMD).The non-ionising radiation emitted by REMS allows it to be used in previously underserved populations including pregnant women and children and may facilitate more frequent measurement of BMD.
View Article and Find Full Text PDFPreventing falls in older adults requires a comprehensive approach that distinguishes between accidental falls and falls related to underlying medical problems, such as syncope. For unintentional falls, prevention follows a three-stage model. The primary level focuses on encouraging regular physical activity, assessing, and reducing footwear and environmental risks, managing comorbidities, and promoting healthy lifestyles.
View Article and Find Full Text PDFBackground: Low grip strength and gait speed are associated with mortality. However, investigation of the additional mortality risk explained by these measures, over and above other factors, is limited.
Aim: We examined whether grip strength and gait speed improve discriminative capacity for mortality over and above more readily obtainable clinical risk factors.
Content validity of SarQoL, a quality of life questionnaire specific to sarcopenia.
Aging Clin Exp Res
April 2024
Background: The Sarcopenia & Quality of Life (SarQoL) questionnaire is a patient-reported outcome measure designed for assessing health-related quality of life in individuals with sarcopenia. Despite its wide acceptance in the scientific literature, its content validity has only been partially demonstrated so far.
Aims: To enhance the evidence supporting the content validity of the SarQoL questionnaire.
Background: Health literacy (HL) has been put forward as a potential mediator through which socioeconomic status (SES) affects health. This study explores whether HL mediates the relation between SES and a selection of health or health-related outcomes.
Methods: Data from the participants of the Belgian health interview survey 2018 aged 18 years or older were individually linked with data from the Belgian compulsory health insurance (n = 8080).
Objectives: To evaluate some confounding factors that influence the concentrations of S100 calcium binding protein B (S100B), glial fibrillary acidic protein (GFAP), and ubiquitin carboxyl-terminal hydrolase L-1 (UCH-L1) in older individuals. Indeed, recent guidelines have proposed the combined use of S100B and the "GFAP-UCH-L1" mTBI test to rule out mild traumatic brain injuries (mTBI). As older adults are the most at risk of mTBI, it is particularly important to understand the confounding factors of those mTBI rule-out biomarkers in aging population.
View Article and Find Full Text PDFThe role and impact of health economics in the optimization of patient care in osteoarthritis: insights from a practical example.
Glob Reg Health Technol Assess
April 2024
Article Synopsis
- * Health economics and health technology assessment (HTA) are important tools to evaluate healthcare technologies and interventions for OA by analyzing their clinical, economic, and ethical dimensions.
- * The article discusses a cost-effectiveness analysis of hyaluronic acid treatment for knee OA, highlighting the challenges faced by HTA, such as limited data and resources, while emphasizing the benefits of integrating health economics into healthcare decision-making.
Article Synopsis
- Sarcopenia is when people lose muscle mass and strength as they get older, and there's no clear agreement on what it exactly means worldwide.
- A group called the Global Leadership Initiative in Sarcopenia (GLIS) worked to define sarcopenia better by getting experts from around the world to share their opinions.
- They found that most experts agreed that things like muscle mass and strength are really important to understanding sarcopenia and that it becomes more common as people age.
Objective: To identify a microRNA signature associated to sarcopenia in community-dwelling older adults form the SarcoPhAge cohort.
Methods: In a screening phase by next generation sequencing (NGS), we compared the hsa-miRome expression of 18 subjects with sarcopenia (79.6 ± 6.
Article Synopsis
- Osteoporosis has traditionally been seen as a women's disease, but recent evidence highlights its significant impact on men, necessitating more balanced research and guidelines for both genders.
- An international working group has developed GRADE-assessed recommendations focusing on diagnosing, monitoring, and treating osteoporosis in men, based on a thorough review of current research.
- Key areas of focus include understanding bone densitometry interpretations, treatment thresholds, and evaluating the economic impact of interventions, while future research needs to explore the effectiveness of various osteoporosis medications.
Article Synopsis
- Clinical Practice Guidelines (CPGs) are rules for treating hip and knee osteoarthritis but often give different advice, making it hard to follow them effectively.
- A study reviewed 25 different CPGs from various countries to see how good they are and found that some guidelines ranked better than others, especially those from ACR and NICE.
- The findings suggest that better quality guidelines will lead to more agreement among them, and future CPGs should be based on strong evidence and clear rules to help everyone stay on the same page.