Elevated morbidity and health care use in children with obstructive sleep apnea syndrome.

Rationale: Health care use, a reliable measure of morbidity, is noticeably higher 1 yr before obstructive sleep apnea syndrome (OSAS) diagnosis in preschool children. It is not clear at what age OSAS-related morbidity becomes expressed.

Objective: To explore morbidity and health care use among children with OSAS starting from first year of life.

Polysomnographic and actigraphic evidence of sleep fragmentation in patients with irritable bowel syndrome.

Study Objective: To characterize the function and quality of sleep in patients with irritable bowel syndrome (IBS).

Design: A prospective study with a historic comparison group.

Setting: A regional hospital that also serves as a tertiary referral center.

Sleep disruption and objective sleepiness in children with beta-thalassemia and congenital dyserythropoietic anemia.

Background: Sleep fragmentation and periodic leg movement syndrome (PLMS) have been reported in adults with iron deficiency anemia. Little is known about sleep function and daytime sleepiness in children with chronic anemia such as beta-thalassemia or congenital dyserythropoietic anemia type 1 (CDA-1).

Objectives: To investigate if children and adolescents who have beta-thalassemia (major or intermedia) or CDA-1 experience sleep fragmentation and objective daytime sleepiness and also to investigate if children and adolescents with beta-thalassemia have obstructive sleep apnea.