Breast cancer: influence of tumour volume estimation method at MRI on prediction of pathological response to neoadjuvant chemotherapy.

Objective: Does method of tumour volume measurement on MRI influence prediction of treatment outcome in patients with primary breast cancer undergoing neoadjuvant chemotherapy (NAC)?.

Method: The study comprised of 136 women with biopsy-proven breast cancer scheduled for MRI monitoring during NAC treatment. Dynamic contrast-enhanced images were acquired at baseline (pre-NAC) and interim (post three NAC cycles) time points.

Quantitative MRI evaluation of whole abdomen adipose tissue volumes in healthy volunteers-validation of technique and implications for clinical studies.

Objective: To explore "whole abdomen" MRI methods for quantifying adipose tissue volumes and to establish associations with body mass index (BMI) and measurement reproducibility-relative to existing "partial abdomen" methods.

Methods: 15 healthy volunteers were scanned on a 3T MRI scanner using a double-echo three-point-Dixon gradient echo sequence. Whole abdomen volumes were acquired via three separate scans ("supine 1", "supine 2" and "prone").