Publications by authors named "Bruno Vicente"
Trichomoniasis, a prevalent sexually transmitted infection (STI) caused by the protozoan Trichomonas vaginalis, has gained increased significance globally. Its relevance has grown in recent years due to its association with a heightened risk of acquiring and transmitting the human immunodeficiency virus (HIV) and other STIs. In addition, many publications have revealed a potential link between trichomoniasis and certain cancers.
View Article and Find Full Text PDFArticle Synopsis
- Visceral leishmaniasis (VL) is a chronic disease in Brazil caused by specific parasites, with extracellular vesicles (Leish-EVs) playing a role in how the host immune system responds to the infection.
- The study found that Leish-EVs are released more when the parasites grow at higher temperatures, and the presence of these vesicles in the host cells can help differentiate between infected and uninfected individuals.
- THP-1 cells exposed to Leish-EVs showed altered immune responses, producing certain interleukins and microRNAs, indicating that Leish-EVs could contribute to immunosuppression and worsen the disease in infected hosts.
Article Synopsis
- - Giardiasis, caused by a protozoan and affecting around 400 million people globally, particularly impacts children, leading to serious health complications and intellectual deficits when undiagnosed.
- - There are various diagnostic methods available, including microscopic, immunological, and molecular techniques, making it difficult to choose the best one.
- - The review highlights that microscopic methods, especially Ritchie's method, are the most reliable for diagnosing giardiasis, with PCR being less used due to costs in developing countries; in cases of persistent symptoms with negative results, more sensitive tests should be considered.
Purpose: To evaluate the acute hepatotoxicity of Equisentum arvense L. in rats.
Methods: Fifty Wistar rats were used, these being divided in four groups, one being the control (receiving only water) and the other groups receiving graded doses of Equisentum arvense L.
In this work, we evaluate the structural differences of transmembrane helix 3 in rhodopsin and the 5-hydroxytryptamine 1A (5-HT1A) receptor caused by their different amino acid sequence. Molecular dynamics simulations of helix 3 in the 5-HT1A receptor tends to bend toward helix 5, in sharp contrast to helix 3 in rhodopsin, which is properly located within the position observed in the crystal structure. The relocation of the central helix 3 in the helical bundle facilitates the experimentally derived interactions between the neurotransmitters and the Asp residue in helix 3 and the Ser/Thr residues in helix 5.
View Article and Find Full Text PDF