A Paleoarchaean impact crater in the Pilbara Craton, Western Australia.

The role of meteorite impacts in the origin, modification, and destruction of crust during the first two billion years of Earth history (4.5-2.5 billion years ago; Ga) is disputed.

Pharmacological inhibition of key metabolic pathways attenuates Leishmania spp infection in macrophages.

Macrophages represent a fundamental component of the innate immune system that play a critical role in detecting and responding to pathogens as well as danger signals. Leishmania spp. infections lead to a notable alteration in macrophage metabolism, whereby infected cells display heightened energy metabolism that is linked to the integrity of host mitochondria.