Publications by authors named "Bruno Tavares"

Article Synopsis
  • The text discusses the importance of healthy eating habits for children's growth, emphasizing the need for educational interventions at schools and involvement from families to improve complementary feeding practices.
  • The objective of the review is to evaluate how effective early childhood education interventions are in enhancing complementary feeding practices for children aged 4 to 36 months.
  • The review will include various types of studies (like randomized trials and observational studies) and will follow a systematic methodology for collecting and evaluating data from multiple databases without limits on date or language.
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Background: Assessing the risk of multidrug-resistant colonization and infections is pivotal for optimizing empirical therapy in hematopoietic stem cell transplants (HSCTs). Limited data exist on extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) colonization in this population. This study aimed to assess whether ESBL-E colonization constitutes a risk factor for ESBL-E bloodstream infection (BSI) and to evaluate ESBL-E colonization in HSCT recipients.

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  • A quality improvement initiative in Brazil started in 2018 aimed to decrease healthcare-associated infections in ICUs, achieving significant reductions over two years.
  • As the COVID-19 pandemic unfolded, the initiative made necessary adaptations to continue its efforts.
  • The study highlights how the pandemic influenced the outcomes of the quality improvement project.
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Background: High rates of antibiotic use (AU) among inpatients with coronavirus disease 2019 (COVID-19) despite low rates of bacterial coinfection and secondary infection have been reported. We evaluated the impact of the COVID-19 pandemic on AU in healthcare facilities (HCFs) in South America.

Methods: We conducted an ecologic evaluation of AU in inpatient adult acute care wards in 2 HCFs each in Argentina, Brazil, and Chile.

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Article Synopsis
  • - This study evaluated the rates of Healthcare-Associated Infections (HAIs) and antimicrobial consumption in ICUs in São Paulo during the COVID-19 pandemic, comparing data with the years before the pandemic.
  • - Researchers analyzed data from 220 ICUs and found a significant rise in Central-Line-Associated Bloodstream Infections (CLABSI) following the pandemic, influenced by hospital size, type of funding, and catheter usage, while Ventilator-Associated Pneumonia (VAP) rates increased in public hospitals with higher mechanical ventilation use.
  • - Despite a notable uptick in HAIs and increased use of broad-spectrum antibiotics during the pandemic, the susceptibility of the microorganisms remained unchanged compared to the pre-pandemic period.
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Background: Although there are simple and low-cost measures to prevent healthcare-associated infections (HAIs), they remain a major public health problem. Quality issues and a lack of knowledge about HAI control among healthcare professionals may contribute to this scenario. In this study, our aim is to present the implementation of a project to prevent HAIs in intensive care units (ICUs) using the quality improvement (QI) collaborative model Breakthrough Series (BTS).

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In this large cohort of healthcare workers, we aimed to estimate the rate of reinfections by SARS-CoV-2 over 2 years of the COVID-19 pandemic. We investigated the proportion of reinfections among all the cases of SARS-CoV-2 infection from March 10, 2020 until March 10, 2022. Reinfection was defined as the appearance of new symptoms that on medical evaluation were suggestive of COVID-19 and confirmed by a positive RT-PCR.

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Article Synopsis
  • Sonothrombolysis, which involves using high mechanical index impulses during an intravenous microbubble infusion, can improve myocardial perfusion in patients with acute ST segment elevation myocardial infarction, but its impact on diastolic dysfunction and left atrial mechanics was assessed for the first time.
  • In a study with 100 patients split into two groups (therapy plus PCI vs. PCI only), those receiving sonothrombolysis showed less worsening of diastolic dysfunction and better left atrial mechanics over a follow-up period.
  • Overall, the therapy group experienced significantly improved left atrial global longitudinal strain and were less likely to undergo left atrial remodeling compared to the control group, suggesting that sonothrombolysis may offer protective benefits
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Article Synopsis
  • The incidence of multidrug resistant organisms (MDROs), particularly carbapenem-resistant Gram-negative bacteria and vancomycin-resistant Enterococcus, is significantly high among solid organ transplant (SOT) patients in Brazil.
  • This review highlights issues in antimicrobial use and resistance, focusing on the challenges and opportunities for establishing effective antimicrobial stewardship programs (ASPs) within Brazilian hospitals.
  • Key barriers to implementing ASPs include lack of specific national guidelines for SOT patients, inadequate electronic medical records, limited rapid diagnostic testing, and insufficient time for healthcare personnel to devote to stewardship activities.
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Objective: To evaluate pain and mobility in patients with transtrochanteric fractures subjected to osteosynthesis with pericapsular nerve group (PENG) block and compare with patients who did not receive the block.

Methods: The medical records of 49 patients were analyzed and data were collected regarding: age, gender, anesthetic evaluation, cause of trauma, locomotion, fracture classification, type of anesthesia used, anesthetic technique, pain, opioid administration and mobility with partial load.

Results: Out of 49 patients, 17 (34.

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This is a cross-sectional study conducted with 492 riverine residents in the rural area of Coari (AM) to identify food patterns in the mid-Solimões river region and associated factors. Food intake was evaluated using a brief Food Frequency Questionnaire (FFQ), and principal component analysis was used to identify dietary patterns. The association with socioeconomic variables was evaluated using generalized linear models.

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Purpose: The aim of this study was to describe the incidence and risk factors for hospital readmission and infection during the months after COVID-19 hospital admission.

Methods: This prospective study included adult patients who were hospitalized due to COVID-19 and had been discharged from April 2020 to August 2020. All patients had a medical evaluation with a structured questionnaire 6 to 11 months after hospital admission.

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Background: It has recently been demonstrated that the application of high-energy ultrasound and microbubbles, in a technique known as sonothrombolysis, dissolves intravascular thrombi and increases the angiographic recanalization rate in patients with ST-segment-elevation myocardial infarction (STEMI).

Objective: To evaluate the effects of sonothrombolysis on left ventricular wall motion and myocardial perfusion in patients with STEMI, using real-time myocardial perfusion echocardiography (RTMPE).

Methods: One hundred patients with STEMI were randomized into the following 2 groups: therapy (50 patients treated with sonothrombolysis and primary coronary angioplasty) and control (50 patients treated with primary coronary angioplasty).

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Article Synopsis
  • - Clostridioides difficile (CD) is the leading cause of diarrhea in healthcare settings, and its severity has grown due to more aggressive strains.
  • - The primary factor for CD's virulence is toxin production, but the study found other important genetic factors contributing to its virulence.
  • - Researchers sequenced 38 strains and found most were toxigenic, with some lacking genes related to adhesion, highlighting the need to explore other virulence factors for a better understanding of CD.
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Ischiofemoral impingement (IFI), although infrequent, should be thought of as one of the causes of deep gluteal pain syndrome. Difficulty in establishing a diagnosis and inaccurate clinical examination can be associated with the small number of case reports in the literature. The initial IFI treatment uses conservative measures, and surgical treatment is infrequent.

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Article Synopsis
  • - The study evaluated the occurrence of COVID-19 among patients in hemodialysis facilities in São Paulo, finding 1,093 reported cases out of 20,984 patients surveyed.
  • - Many facilities implemented preventive measures like dedicated COVID-19 areas and symptom screening, yet about 56% experienced at least one cluster of cases, with clustering suspected in only 7% of facilities.
  • - The primary risk factor for clustering was linked to aerosol-generating procedures, suggesting the need for caution in such practices to reduce transmission and monitor outbreaks effectively.
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The article presents methodological aspects of anthropometric assessment of nutritional status in children under five years of age and their biological mothers. It discusses the strategies used for training and data collection in the Brazilian National Survey on Child Nutrition (ENANI-2019). ENANI-2019 is a population-based household survey conducted in 123 municipalities in Brazil's 26 states and the Federal District.

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This study aimed to verify the association between work and sociodemographic factors, health behaviors, and cardiovascular risk in Brazilian adolescents. Data from the Study of Cardiovascular Risks in Adolescents (ERICA) were analyzed, with a sample of 37,815 adolescents aged 12-17 years and morning shift students. Considering complex sampling, crude and adjusted Prevalence Ratios (PR) were calculated with interval estimates for variables by Poisson multiple regression model with robust variance estimate.

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Introduction: Different therapies are currently used, considered, or proposed for the treatment of COVID-19; for many of those therapies, no appropriate assessment of effectiveness and safety was performed. This document aims to provide scientifically available evidence-based information in a transparent interpretation, to subsidize decisions related to the pharmacological therapy of COVID-19 in Brazil.

Methods: A group of 27 experts and methodologists integrated a task-force formed by professionals from the Brazilian Association of Intensive Care Medicine (Associação de Medicina Intensiva Brasileira - AMIB), the Brazilian Society of Infectious Diseases (Sociedad Brasileira de Infectologia - SBI) and the Brazilian Society of Pulmonology and Tisiology (Sociedade Brasileira de Pneumologia e Tisiologia - SBPT).

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Background: It has recently been demonstrated that high-energy diagnostic transthoracic ultrasound and intravenous microbubbles dissolve thrombi (sonothrombolysis) and increase angiographic recanalization rates in patients with ST-segment-elevation myocardial infarction. We aimed to study the effect of sonothrombolysis on the myocardial dynamics and infarct size obtained by real-time myocardial perfusion echocardiography and their value in preventing left ventricular remodeling.

Methods: One hundred patients with ST-segment-elevation myocardial infarction were randomized to therapy (50 patients treated with sonothrombolysis and percutaneous coronary intervention) or control (50 patients treated with percutaneous coronary intervention only).

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The buffy coat is obtained routinely for disseminated histoplamosis (DH) diagnosis in Ceará, Brazil. The aim of this study is to describe the accuracy of staining smears for in the buffy coat of AIDS-patients with DH. From 2012-2013, all results of stained buffy coat smears and culture for fungi performed at São José Hospital were recorded.

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Article Synopsis
  • * Data from 71,298 adolescents aged 12 to 17 were analyzed, revealing three primary dietary patterns (traditional, bread-and-coffee, and unhealthy), with a fourth unique pattern specific to North Brazil.
  • * The findings indicated that males had a stronger preference for traditional foods, while private school students tended to consume more unhealthy foods, suggesting a link between socioeconomic status and dietary habits.
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Article Synopsis
  • Preclinical studies indicate that high mechanical index (MI) ultrasound impulses can enhance blood flow during treatment for ST-segment elevation myocardial infarction (STEMI).
  • A clinical trial involving 100 patients tested sonothrombolysis combined with standard percutaneous coronary intervention (PCI) against PCI alone to evaluate its effects on heart function and recovery.
  • Results showed that patients receiving sonothrombolysis had significantly better outcomes in terms of heart function improvement, reduced infarct size, and higher rates of blood flow restoration compared to those who only underwent PCI.
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Background: and purpose: Yoga is growing in popularity, but its benefits and integration into primary care remain uncertain. Here, we determine yoga effects on quality of life and psychological distress, and evaluate the feasibility of introducing yoga at primary care level.

Materials And Methods: This is a prospective, longitudinal, quasi-experimental study, with an intervention (n = 49) and a control group (n = 37).

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