From the Shelf to the Particle: Preparation of Highly Organic-Functionalized Magnetic Composites via 4-Nitrophenyl Reactive Ester.

Preparation of chemically tunable magnetic nanoparticles (MNPs) is of great interest in many technological fields. Although numerous methods have been developed to prepare MNPs coated with functional organic moieties, most of them are complex, multistep, and involve the preparation of a specific ligand to be inserted on the particle surface. Herein, we describe the preparation of MNPs covered with reactive polymer poly(4-nitrophenyl methacrylate).

Histamine functionalized magnetic nanoparticles (HIS-MNP) as a sorbent for thin film microextraction of endocrine disrupting compounds in aqueous samples and determination by high performance liquid chromatography-fluorescence detection.

This paper describes the development of a new method in which histamine-functionalized magnetic nanoparticles (HIS-MNP) are used as the extraction phase associated with thin-film microextraction and a 96-well plate system. This approach was applied to the determination of estrone, estriol, 17-β-estradiol, 17α-ethynylestradiol, 4-octylphenol and 4-nonylphenol in aqueous samples by HPLC-FLD. Extraction and liquid desorption steps were optimized employing multivariate and univariate procedures.