Publications by authors named "Bruno Sempere"
JCI Insight
February 2023
Article Synopsis
- The study investigates how lung epithelial cells and fibroblasts interact in a model that mimics idiopathic pulmonary fibrosis (IPF), revealing that the initial population of epithelial cells is diverse and includes some with a basal cell identity.
- Analysis showed that these cells and fibroblasts undergo different pro-fibrotic changes when cultured together, similar to those found in IPF patients' lungs.
- The research highlights NF-κB signaling as a key factor in this process, linking epithelial dysfunction to fibrosis and suggesting that blocking NF-κB could reduce harmful cell changes and inflammation.
