Mutagenic activity of overnight urine from healthy non-smoking subjects.

Urinary mutagenicity was evaluated in relation to environmental mutagen exposure (i.e., diet, indoor/outdoor activities, residential area etc.

Determinants of anti-benzo[a]pyrene diol epoxide-DNA adduct formation in lymphomonocytes of the general population.

We evaluated determinants of anti-benzo[a]pyrenediolepoxide-(B[a]PDE)-DNA adduct formation (adduct induced by the ultimate carcinogenic metabolite of B[a]P) in lymphomonocytes of subjects environmentally exposed to low doses of polycyclic aromatic hydrocarbons (PAHs) (B[a]P). Our study population consisted of 585 Caucasian subjects, all municipal workers living in North-East Italy and recruited during their periodic check-ups after informed consent. PAH (B[a]P) exposure was assessed by questionnaire.

Increased cancer risk among surgeons in an orthopaedic hospital.

Background: Five cancer cases over 7 years were reported in a small orthopaedic hospital where radiation protection practice was poor.

Aim: To investigate whether workers subject to routine radiation dosimetric assessment in that hospital had an increased cancer risk.

Methods: One hundred and fifty-eight workers subject to routine dose assessment and 158 age-sex-matched unexposed workers were questioned about cancer occurrence.