Histamine functionalized magnetic nanoparticles (HIS-MNP) as a sorbent for thin film microextraction of endocrine disrupting compounds in aqueous samples and determination by high performance liquid chromatography-fluorescence detection.

This paper describes the development of a new method in which histamine-functionalized magnetic nanoparticles (HIS-MNP) are used as the extraction phase associated with thin-film microextraction and a 96-well plate system. This approach was applied to the determination of estrone, estriol, 17-β-estradiol, 17α-ethynylestradiol, 4-octylphenol and 4-nonylphenol in aqueous samples by HPLC-FLD. Extraction and liquid desorption steps were optimized employing multivariate and univariate procedures.

Positive impact of a clinical goal-directed protocol on reducing cardiac arrests during potential brain-dead donor maintenance.

Background: The disproportion between the large organ demand and the low number of transplantations performed represents a serious public health problem worldwide. Reducing the loss of transplantable organs from deceased potential donors as a function of cardiac arrest (CA) may contribute to an increase in organ donations. Our purpose was to test the hypothesis that a goal-directed protocol to guide the management of deceased donors may reduce the losses of potential brain-dead donors (PBDDs) due to CA.