Preparation and characterization of bioadhesive system containing hypericin for local photodynamic therapy.

Hypericin (Hyp) is a natural photoactive pigment utilized in the treatment of different types of cancer and antimicrobial inactivation using photodynamic therapy (PDT). Hyp is poorly soluble in water leading to problems of administration, getting close contact with the site, and bio-availability. Therefore, this study aimed to develop bioadhesive thermoresponsive system containing Hyp for local PDT.

Photodynamic Inactivation Mediated by Erythrosine and its Derivatives on Foodborne Pathogens and Spoilage Bacteria.

The purpose of the present study was to evaluate the efficacy of photodynamic inactivation (PDI) mediated by erythrosine (ERY) and its ester derivatives erythrosine methyl ester (ERYMET) and erythrosine butyl ester (ERYBUT) on foodborne pathogens and spoilage bacteria. We evaluated Staphylococcus aureus ATCC 25923, Aeromonas hydrophila ATCC 7966, Salmonella enterica serotype Typhimurium ATCC 14028, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853. The toxicity of all of the compounds was assessed in VERO cells.

[Evaluation of antimicrobial activity antiseptics and disinfectants used in a public health service].

The study aimed to determine the in vitro antimicrobial activity of antiseptics and disinfectant used in the care service primary health of a city in northern Paraná, using microorganisms standardized by the National Institute of Quality Control in Health, Oswaldo Cruz Foundation. For this purpose, we performed tests of antimicrobial activity and chemical stability of three samples of antiseptic and one disinfectant used in the service. From the analysis performed the first, seventh, fourteenth and twenty-first day after the opening of the bottles, it was found that the samples retained their activity in vitro antimicrobial regarding standardized strains, as evidenced by the absence of growth of colony-forming units and maintaining the chemical stability.