Publications by authors named "Bruno Pereira Crulhas"
Article Synopsis
- Cell culture is vital for studying cell biology, and the shift towards in vitro models that better mimic real-life conditions has led to the development of tridimensional (3D) cell cultures.
- This review focuses on constructing 3D spheroids through a magnetic technique involving gold and iron oxide nanoparticles, which facilitates advanced cell culture methods like levitation and bioprinting.
- Recent advancements in magnetic 3D cell cultures are explored, covering applications in tumor microenvironments, tissue engineering, and studying various cell types, contributing to fields such as toxicology and biomedical research.
Gold nanoparticles (AuNPs) can provide a simple, easy-to-use, inexpensive, at hand point-of-care (POC) fast to diagnose; however, AuNPs have the predisposition to form aggregations. Since the nanoparticles stability is an important issue, this article is aiming to study the long-term stability associated with the development of an immunosensor for clinical diagnosis. Here, we assessed two previous methods commonly described in the literature to prevent the formation of aggregate by studying pH and Tween® 20 (polysorbates) addition as surfactant.
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- The study investigates the efficacy of cinnamaldehyde, a natural product, against Staphylococcus epidermidis, particularly focusing on its ability to inhibit bacterial growth and biofilm formation in the context of rising antibiotic resistance.
- Results showed that cinnamaldehyde has a minimum inhibitory concentration (MIC) of 300 to 500 μg/mL and can significantly reduce biofilm formation, with higher concentrations needed to target established biofilms.
- Additionally, the combination of cinnamaldehyde with the antibiotic linezolid demonstrated a potent bactericidal effect, indicating its potential as a new antimicrobial agent.