Publications by authors named "Bruno P Setatino"
Massive vaccination positively impacted the SARS-CoV-2 pandemic, being a strategy to increase the titers of neutralizing antibodies (NAbs) in the population. Assessing NAb levels and understanding the kinetics of NAb responses is critical for evaluating immune protection. In this study, we optimized and validated a PRNT assay to assess 50% virus neutralization and evaluated its accuracy to measure NAbs to the original strain or variant of SARS-CoV-2.
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- Bovine lactoferrin (bLf) exhibits significant antiviral activity against SARS-CoV-2, including the omicron variant, potentially providing a new therapeutic option.
- Both unsaturated (apo-bLf) and saturated (holo-bLf) forms reduced virus infection by around 70% when present during infection, with effectiveness peaking in the early stages of infection.
- Holo-bLf showed slightly better efficacy in preventing virus entry compared to apo-bLf, indicating that bLf could be a promising treatment for COVID-19 due to its low toxicity and significant inhibitory effects.
Infections caused by SARS-CoV-2 induce a severe acute respiratory syndrome called COVID-19 and have led to more than six million deaths worldwide. Vaccination is the most effective preventative measure, and cellular and humoral immunity is crucial to developing individual protection. Here, we aim to investigate hybrid immunity against SARS-CoV-2 triggered by the ChAadOx1 nCoV-19 vaccine in a Brazilian cohort.
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