Publications by authors named "Bruno Miguel Fonseca"
Article Synopsis
- Preeclampsia (PE) is a complication in pregnancy with limited biomarkers available for assessing its severity and type.
- Recent research has highlighted the role of the endocannabinoid system (eCBome) in placental health, revealing that certain molecules show altered levels in PE patients' placental tissues.
- Findings suggest that lower levels of key endocannabinoids in the placenta and plasma may contribute to the inflammatory nature of PE and the abnormal changes in blood vessels associated with the condition, indicating potential for these biomarkers in future studies.
The endocannabinoid system has evolved as a key regulator in several pathological and physiological processes, including placentation, decidualization and implantation. In addition, it is known that Cannabis and cannabinoids negatively affect female reproduction. Although, the biological action of synthetic cannabinoids, such as WIN-55,212, in human fertility and pregnancy outcome remain to be unveiled.
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