First epidemiological data from the French Trophoblastic Disease Reference Center.

Objective: The objective of the study was to describe women registered at the new French Trophoblastic Disease Reference Center and particularly the rates of gestational trophoblastic neoplasia (GTN) after molar pregnancies.

Study Design: Epidemiological data from a prospective cohort of women registered between November 1999 and November 2004 were analyzed.

Results: Four hundred forty-eight women were registered.

Anabolic and catabolic hormonal responses to experimental two-set low-volume resistance exercise in sedentary and active elderly people.

Background And Aims: The influence of acute low-volume resistance exercise on serum growth hormone (GH), insulin-like growth factor I (IGF-I), dehydroepiandrosterone sulphate (DHEAS), total testosterone (TT) and cortisol was ascertained in elderly subjects.

Methods: Forty-seven independent, community-dwelling volunteers aged >65 years were recruited: 23 (11 men, 12 women) were sedentary individuals, and 24 (12 men, 12 women) had been regularly involved in physical activity for several years. The protocol consisted of two sets of leg extensions: one graded by loading to reach maximal power; the other consisted of 10 consecutive leg extensions using a load corresponding to maximal power.

Testosterone measured by 10 immunoassays and by isotope-dilution gas chromatography-mass spectrometry in sera from 116 men, women, and children.

Background: Commercially available testosterone immunoassays give divergent results, especially at the low concentrations seen in women. We compared immunoassays and a nonimmunochemical method that could quantify low testosterone concentrations.

Methods: We measured serum testosterone in 50 men, 55 women, and 11 children with use of eight nonisotopic immunoassays, two isotopic immunoassays, and isotope-dilution gas chromatography-mass spectrometry (ID/GC-MS).

Glucocorticoid-induced maturation of glycoprotein galactosylation and fucosylation processes in the rat small intestine.

We determined the role of glucocorticoids in the maturation of glycoprotein galactosylation and fucosylation processes in the rat small intestine during postnatal development. Treatment of suckling rats with hydrocortisone (HC) increased activities of an O-glycan: galactosyltransferase, and of an alpha-1,2-fucosyltransferase, through transcriptional regulation of the FTB gene. The activities of a fucosyltransferase inhibitor and of the enzymes responsible for the synthesis and degradation of GDP-fucose were unaffected by the treatment, whereas a fall in the activity of alpha-L-fucosidase was observed.